Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27845557 | 0.90 | ELANE (0.42) | ELANEMAOBATML3MBTL1TDP1 | |
| SCHEMBL19432834 | 0.89 | ELANE (0.42) | ELANEMAOBHDAC1HDAC2ATM | |
| SCHEMBL26061847 | 0.87 | ELANE (0.47) | ELANEMAOBATML3MBTL1TDP1 | |
| SCHEMBL10187806 | 0.86 | ELANE (0.44) | ELANEMAOBHDAC1HDAC2ATM | |
| SCHEMBL24360919 | 0.84 | ELANE (0.45) | ELANEMAOBHDAC1HDAC2ATM | |
| SCHEMBL1255890 | 0.81 | ELANE (0.47) | ELANEMAOBHDAC1HDAC2ATM | |
| SCHEMBL9086925 | 0.81 | ELANE (0.41) | ELANEMAOBHDAC1HDAC2ATM | |
| SCHEMBL544447 | 0.79 | MAOB (0.49) | ELANEMAOBHDAC1HDAC2ATM | |
| SCHEMBL10946374 | 0.79 | ELANE (0.46) | ELANEMAOBHDAC1HDAC2ATM | |
| SCHEMBL7176961 | 0.78 | ELANE (0.42) | ELANEMAOBHDAC1HDAC2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486923-B1 | Histone deacetylase (HDAC) inhibiting compounds and method of making same | FELIX JÄGER UND DR STEFAN DRINKUTH LABORGEMEINSCHAFT OHG DR (DE) | 2015-09-09 | — | — | EP | disclosed |
| WO-2012107304-A1 | HISTONE DEACETYLASE (HDAC) INHIBITING COMPOUNDS AND METHOD OF MAKING SAME | Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG (DE) | 2012-08-16 | — | — | WO | disclosed |
| EP-2486923-A1 | Histone deacetylase (HDAC) inhibiting compounds and method of making same | Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG (DE) | 2012-08-15 | — | — | EP | disclosed |