Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11925797 | 0.88 | PIK3CA (0.49) | KIF11PIK3CDPIK3CAMTORMEN1 | |
| SCHEMBL8206190 | 0.86 | PIK3CD (0.43) | KIF11PIK3CDPIK3CAMTORMEN1 | |
| SCHEMBL11925317 | 0.84 | KIF11 (0.42) | KIF11PIK3CDPIK3CAMTORMEN1 | |
| SCHEMBL8214242 | 0.83 | CYP3A4 (0.44) | PIK3CDPIK3CAMTORALDH1A1CYP2C19 | |
| SCHEMBL8104043 | 0.80 | PIK3CA (0.45) | PIK3CDPIK3CAMTORMEN1ALDH1A1 | |
| SCHEMBL8213981 | 0.80 | KIF11 (0.42) | KIF11PIK3CDPIK3CAMTORMEN1 | |
| SCHEMBL11926115 | 0.79 | KIF11 (0.39) | KIF11PIK3CDPIK3CAMTORKMT2A | |
| SCHEMBL8218355 | 0.79 | PIK3CA (0.38) | KIF11PIK3CDPIK3CAMTORMEN1 | |
| SCHEMBL8217031 | 0.79 | KIF11 (0.44) | KIF11PIK3CDPIK3CAMTORMEN1 | |
| SCHEMBL8099372 | 0.79 | PIK3CA (0.48) | PIK3CDPIK3CAMTORMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |