Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.42 |
| ▸ | MTOR | P42345 | 5/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218760 | 0.93 | ATM (0.43) | PIK3CAMTORPIK3CDEPHX2 | |
| SCHEMBL8212640 | 0.90 | PIK3CA (0.51) | PIK3CAMTORPIK3CDKLKB1EPHX1 | |
| SCHEMBL8213870 | 0.87 | PIK3CA (0.43) | PIK3CAMTORPIK3CD | |
| SCHEMBL11924820 | 0.86 | CA12 (0.45) | PIK3CAMTORPIK3CDCA12CA1 | |
| SCHEMBL8213164 | 0.85 | PIK3CA (0.55) | PIK3CAMTORPIK3CD | |
| SCHEMBL11925317 | 0.84 | KIF11 (0.42) | PIK3CAMTORPIK3CD | |
| SCHEMBL8219567 | 0.84 | PIK3CA (0.42) | PIK3CAMTORPIK3CDKLKB1EPHX1 | |
| SCHEMBL8206186 | 0.84 | RAB9A (0.45) | PIK3CAMTORPIK3CDPOLBEPHX1 | |
| SCHEMBL8218988 | 0.84 | FPR2 (0.39) | PIK3CAMTORPIK3CDPOLBEPHX1 | |
| SCHEMBL8219487 | 0.83 | PIK3CA (0.40) | PIK3CAMTORPIK3CDKLKB1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |