Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204668 | 0.82 | PTGS2 (0.41) | PTGS2PIK3CAPIK3R1MTORMEN1 | |
| SCHEMBL8214158 | 0.82 | PTGS2 (0.44) | PTGS2PIK3CAPIK3R1MEN1ALDH1A1 | |
| SCHEMBL11926143 | 0.80 | PTGS2 (0.42) | PTGS2PIK3CAPIK3R1MEN1ALDH1A1 | |
| SCHEMBL8213031 | 0.80 | PIK3CD (0.40) | PTGS2PIK3CAMTORMEN1ALDH1A1 | |
| SCHEMBL8205327 | 0.79 | PIK3CD (0.39) | PTGS2PIK3CAMEN1ALDH1A1MAPT | |
| SCHEMBL8218351 | 0.79 | PIK3CA (0.42) | PIK3CAPIK3R1MTORKMT2APIK3CD | |
| SCHEMBL11924806 | 0.78 | PIK3CA (0.41) | PIK3CAMTORPIK3CD | |
| SCHEMBL8214586 | 0.78 | NPSR1 (0.47) | PIK3CAPIK3R1MTORMEN1ALDH1A1 | |
| SCHEMBL3591707 | 0.78 | PIK3CD (0.59) | PIK3CAMTORPIK3CDCHEK1ATR | |
| SCHEMBL8216601 | 0.78 | PIK3CA (0.41) | PTGS2PIK3CAMTORMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |