Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.46 |
| ▸ | MTOR | P42345 | 4/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595582 | 0.88 | PIK3CD (0.56) | PIK3CAMTORATRPIK3CD | |
| SCHEMBL3606254 | 0.87 | PIK3CD (0.57) | PIK3CAMTORATRPIK3CD | |
| SCHEMBL3607318 | 0.85 | PIK3CA (0.58) | NPSR1PIK3CAMTORPIK3R1SMN1; SMN2 | |
| SCHEMBL3591707 | 0.85 | PIK3CD (0.59) | PIK3CAMTORATRPIK3CD | |
| SCHEMBL11926804 | 0.83 | PIK3CA (0.51) | NPSR1PIK3CAMTORPIK3R1SMN1; SMN2 | |
| SCHEMBL8205302 | 0.80 | NPSR1 (0.48) | NPSR1PIK3CAMTORPIK3R1SMN1; SMN2 | |
| SCHEMBL8214750 | 0.80 | MTOR (0.50) | NPSR1PIK3CAMTORPIK3R1SMN1; SMN2 | |
| SCHEMBL11925883 | 0.78 | PTGS2 (0.38) | PIK3CAMTORPIK3R1ATRMEN1 | |
| SCHEMBL3588712 | 0.76 | PIK3CD (0.51) | PIK3CAMTORATRPIK3CD | |
| SCHEMBL738650 | 0.74 | PIK3CA (0.72) | PIK3CAMTORPIK3R1ATRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |