Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPEPLD | Q6IQ20 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3118261 | 0.85 | NAPEPLD (0.48) | NAPEPLDPIK3CACNR2NPC1RAB9A | |
| SCHEMBL11926341 | 0.81 | NAPEPLD (0.47) | NAPEPLDPIK3CACNR2BRAF | |
| SCHEMBL3114927 | 0.81 | NAPEPLD (0.46) | NAPEPLDPIK3CA | |
| SCHEMBL11926353 | 0.80 | NAPEPLD (0.51) | NAPEPLDPIK3CABRAF | |
| SCHEMBL11926351 | 0.79 | NAPEPLD (0.49) | NAPEPLDPIK3CABRAF | |
| SCHEMBL11926338 | 0.79 | NAPEPLD (0.47) | NAPEPLDPIK3CABRAF | |
| SCHEMBL11926315 | 0.79 | NAPEPLD (0.52) | NAPEPLDPIK3CABRAF | |
| SCHEMBL3106073 | 0.79 | PIK3CA (0.62) | NAPEPLDPIK3CA | |
| SCHEMBL11926352 | 0.79 | NAPEPLD (0.48) | NAPEPLDPIK3CABRAFKCNQ3KCNQ2 | |
| SCHEMBL11926350 | 0.78 | NAPEPLD (0.49) | NAPEPLDPIK3CATSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236795-B2 | IL-12 modulatory compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2012-08-07 | — | — | US | disclosed |
| US-8236795-B2 | IL-12 modulatory compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2012-08-07 | — | — | US | disclosed |
| US-20100256132-A1 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORPORATION (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100256132-A1 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORPORATION (US) | 2010-10-07 | — | — | US | disclosed |
| US-7696202-B2 | IL-12 modulatory compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2010-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256132-A1 | IL-12 MODULATORY COMPOUNDS | IL2, IL4, IFNG | NAPEPLD 1303/4885PIK3CA 2810/4885PTGER3 428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.