Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10002720 | 0.91 | ALOX5 (0.41) | ALOX5NOD1NOD2AGTR1PCSK9 | |
| SCHEMBL10002719 | 0.91 | ALOX5 (0.41) | ALOX5NOD1NOD2AGTR1PCSK9 | |
| SCHEMBL10003682 | 0.82 | NOD2 (0.44) | ALOX5NOD1NOD2AGTR1PCSK9 | |
| SCHEMBL10003441 | 0.79 | ALOX5 (0.37) | ALOX5NOD1NOD2AGTR1PSEN1 | |
| SCHEMBL10003151 | 0.79 | NPC1 (0.37) | ALOX5NOD1NOD2PSEN1PSEN2 | |
| SCHEMBL10003439 | 0.79 | ALOX5 (0.37) | ALOX5NOD1NOD2AGTR1PSEN1 | |
| SCHEMBL10003150 | 0.79 | NPC1 (0.37) | ALOX5NOD1NOD2PSEN1PSEN2 | |
| SCHEMBL10003163 | 0.79 | NOD1 (0.53) | ALOX5NOD1NOD2AGTR1PCSK9 | |
| SCHEMBL28195762 | 0.76 | ALOX5 (0.60) | ALOX5NOD1NOD2AGTR1PSEN1 | |
| SCHEMBL10002909 | 0.75 | ALOX5 (0.42) | ALOX5NOD1NOD2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120208811-A1 | Aminopyrazole Derivative | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208811-A1 | Aminopyrazole Derivative | FGFR1, FGFR3, FGFR4 | ALOX5 2600/4885NOD1 1738/4885NOD2 2641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.