Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.42 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11931133 | 0.92 | GSK3B (0.49) | GSK3BGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL13998618 | 0.86 | GSK3B (0.54) | GSK3BGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL12953929 | 0.86 | GSK3B (0.71) | GSK3BCCNE1CDK2 | |
| SCHEMBL13998619 | 0.84 | GRIN2B (0.52) | GSK3BGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL11936841 | 0.82 | GSK3B (0.63) | GSK3BCCNE1CDK2 | |
| SCHEMBL12953546 | 0.81 | TRPC3 (0.53) | GSK3BGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL12954092 | 0.80 | GSK3B (0.49) | GSK3BGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL13993128 | 0.79 | TRPC3 (0.49) | GSK3BGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL11931159 | 0.79 | GRIN2B (0.47) | GSK3BGRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL14547312 | 0.79 | TRPC3 (0.43) | GSK3BGRIN2BCYP2D6CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942900-B1 | USE OF PYRAZOLO [1,5-A] PYRIMIDINE DERIVATIVES FOR INHIBITING KINASES METHODS FOR INHIBITING PROTEIN KINASES | MERCK SHARP & DOHME (US) | 2015-06-03 | — | — | EP | disclosed |
| US-8211854-B2 | Methods for inhibiting protein kinases | SCHERING CORPORATION (US) | 2012-07-03 | — | — | US | disclosed |
| US-20100125068-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION | 2010-05-20 | — | — | US | disclosed |
| US-7468372-B2 | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-23 | — | — | US | disclosed |
| US-20070082900-A1 | Methods for inhibiting protein kinases | SCHERING CORPORATION | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082900-A1 | Methods for inhibiting protein kinases | PIM1, AURKC, PIM3 | GSK3B 334/4885GRIN2B 4679/4885CYP2D6 4363/4885 |
| US-20100125068-A1 | METHODS FOR INHIBITING PROTEIN KINASES | PIM1, AURKC, PIM3 | GSK3B 334/4885GRIN2B 4679/4885CYP2D6 4363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.