Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | PKM | P14618 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.60 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6645245 | 0.99 | GAA (0.68) | GAAMAPTPKMKDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL6645238 | 0.89 | GAA (0.60) | GAAMAPTPKMKDM4ETDP1 | |
| SCHEMBL8557293 | 0.81 | MAPT (0.97) | GAAMAPTPKMKDM4ETDP1 | |
| SCHEMBL11931390 | 0.79 | DDAH1 (0.53) | GAAMAPTPKMKDM4ETDP1 | |
| SCHEMBL8973998 | 0.79 | POLB (0.71) | GAAMAPTPKMKDM4ETDP1 | |
| SCHEMBL4164831 | 0.78 | EGFR (0.76) | GAAMAPTPKMKDM4ETDP1 | |
| SCHEMBL8974447 | 0.77 | GAA (0.67) | GAAMAPTPKMKDM4ETDP1 | |
| SCHEMBL11932291 | 0.77 | KDM4E (0.55) | MAPTPKMKDM4ETDP1RAB9A | |
| Bendazol SCHEMBL29539948 | 0.76 | GAA (1.00) | GAAMAPTPKMKDM4ETDP1 | |
| Bendazol SCHEMBL309393 | 0.76 | GAA (1.00) | GAAMAPTPKMKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9102692-B2 | Aminopyrazole derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2015-08-11 | — | — | US | disclosed |
| US-20140315856-A1 | AMINOPYRAZOLE DERIVATIVE | F. HOFFMANN-LA ROCHE AG (CH) | 2014-10-23 | — | — | US | disclosed |
| US-8829199-B2 | Aminopyrazole derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2014-09-09 | — | — | US | disclosed |
| US-20120208811-A1 | Aminopyrazole Derivative | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208811-A1 | Aminopyrazole Derivative | FGFR1, FGFR3, FGFR4 | GAA 3930/4885MAPT 4214/4885PKM 3909/4885 |
| US-20140315856-A1 | AMINOPYRAZOLE DERIVATIVE | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, IL4I1, CYP3A43 | GAA 3862/4885MAPT 4330/4885PKM 2661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.