Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | LOX | P28300 | 1/20 | 0.52 |
| ▸ | TCF4 | P15884 | 2/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.50 |
| ▸ | ACLY | P53396 | 2/20 | 0.49 |
| ▸ | CTSG | P08311 | 1/20 | 0.49 |
| ▸ | CMA1 | P23946 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29457845 | 1.00 | POLB (0.55) | POLBALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL2884607 | 0.86 | LOX (0.66) | POLBALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL3293304 | 0.84 | POLB (0.57) | POLBALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL1100084 | 0.84 | ALDH1A1 (0.59) | POLBALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL9008002 | 0.84 | ALDH1A1 (0.59) | POLBALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL2651155 | 0.84 | POLB (0.61) | POLBALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL15546745 | 0.84 | ALDH1A1 (0.42) | POLBALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL23380392 | 0.83 | CA12 (0.74) | POLBCA12CA1CA2CA9 | |
| SCHEMBL38455 | 0.83 | ALDH1A1 (0.58) | POLBALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL2300229 | 0.83 | CA1 (0.70) | POLBALDH1A1KDM4EKMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 536 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113905785-B | Cystic fibrosis transmembrane conductance regulator | 弗特克斯药品有限公司 | 2024-07-19 | — | — | CN | claimed |
| EP-3946595-B1 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MODULATING AGENTS | VERTEX PHARMA (US) | 2023-11-15 | — | — | EP | claimed |
| EP-3946595-A1 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MODULATING AGENTS | Vertex Pharmaceuticals Incorporated (US) | 2022-02-09 | — | — | EP | claimed |
| CN-113905785-A | Cystic fibrosis transmembrane conductance regulator modulators | 弗特克斯药品有限公司 | 2022-01-07 | — | — | CN | claimed |
| WO-2020206080-A1 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MODULATING AGENTS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-10-08 | — | — | WO | claimed |
| CN-108299255-B | Histone deacetylase 8 selective inhibitor and preparation method and application thereof | 山东大学 | 2020-05-19 | — | — | CN | claimed |
| EP-4225762-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2026-05-27 | — | — | EP | disclosed |
| CN-122074075-A | Solid forms of modulators of cystic fibrosis transmembrane conductance regulator | 弗特克斯药品有限公司 | 2026-05-22 | — | — | CN | disclosed |
| US-12612416-B2 | Modulators of cystic fibrosis transmembrane conductance regulator | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2026-04-28 | — | — | US | disclosed |
| EP-4650348-A1 | CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR | Mitsubishi Tanabe Pharma Corporation (JP) | 2025-11-19 | — | — | EP | disclosed |
| US-20250340574-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2025-11-06 | — | — | US | disclosed |
| US-12421251-B2 | Cystic fibrosis transmembrane conductance regulator modulating agents | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-09-23 | — | — | US | disclosed |
| US-12391680-B2 | Compounds and compositions for the treatment of cystic fibrosis | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2025-08-19 | — | — | US | disclosed |
| US-5130119-A | Sulfonamide or hydroxy fluorine substituted benzene for medical diagnosis | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-07-14 | — | — | US | disclosed |
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4111953-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4029638-A | YARNS, SULFONAMIDE GROUPS | AKZONA (US) | 1977-06-14 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12612416-B2 | Modulators of cystic fibrosis transmembrane conductance regulator | CFTR, CLCN2, CLIC1 | POLB 3639/4885ALDH1A1 4475/4885KDM4E 4300/4885 |
| US-20250340574-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | POLB 3310/4885ALDH1A1 3983/4885KDM4E 4306/4885 |
| US-12391680-B2 | Compounds and compositions for the treatment of cystic fibrosis | CFTR, ABCB11, ABCC5 | POLB 1883/4885ALDH1A1 2567/4885KDM4E 4698/4885 |
| US-12421251-B2 | Cystic fibrosis transmembrane conductance regulator modulating agents | CFTR, SCNN1G, CLCN2 | POLB 4205/4885ALDH1A1 2228/4885KDM4E 4085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.