Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 1.00 |
| ▸ | DUSP3 | P51452 | 2/20 | 1.00 |
| ▸ | NR4A1 | P22736 | 1/20 | 1.00 |
| ▸ | CDC25B | P30305 | 1/20 | 0.75 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.71 |
| ▸ | MAPT | P10636 | 10/20 | 0.71 |
| ▸ | MEN1 | O00255 | 10/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.71 |
| ▸ | POLB | P06746 | 8/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.71 |
| ▸ | RECQL | P46063 | 7/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.71 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | THRB | P10828 | 2/20 | 0.71 |
| ▸ | APEX1 | P27695 | 2/20 | 0.71 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.71 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742612 | 0.94 | AKT1 (0.88) | AKT1DUSP3NR4A1CDC25BATAD2 | |
| SCHEMBL13864202 | 0.93 | AKT1 (0.86) | AKT1DUSP3NR4A1CDC25BATAD2 | |
| SCHEMBL13232952 | 0.93 | AKT1 (0.86) | AKT1DUSP3NR4A1CDC25BATAD2 | |
| SCHEMBL6743451 | 0.92 | AKT1 (0.85) | AKT1DUSP3NR4A1CDC25BATAD2 | |
| SCHEMBL6742448 | 0.89 | AKT1 (0.81) | AKT1DUSP3NR4A1CDC25BATAD2 | |
| SCHEMBL6721111 | 0.89 | AKT1 (0.80) | AKT1DUSP3NR4A1CDC25BATAD2 | |
| SCHEMBL6742722 | 0.86 | AKT1 (1.00) | AKT1DUSP3NR4A1CDC25BATAD2 | |
| SCHEMBL6743582 | 0.84 | ATAD2 (1.00) | AKT1DUSP3NR4A1CDC25BATAD2 | |
| SCHEMBL11942993 | 0.84 | AKT1 (0.72) | AKT1DUSP3NR4A1CDC25BATAD2 | |
| SCHEMBL4759244 | 0.83 | MEN1 (1.00) | AKT1DUSP3NR4A1CDC25BATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230040081-A1 | VACCINIA VIRAL POLYMERASE-MEDIATED VIRAL REPLICATION | IMMUNOLUX INTERNATIONAL CORP. | 2023-02-09 | — | — | US | disclosed |
| US-20120190707-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | SANFORD-BURNHAM RESEARCH INSTITUTE | 2012-07-26 | — | — | US | disclosed |
| US-20120190707-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | SANFORD-BURNHAM RESEARCH INSTITUTE | 2012-07-26 | — | — | US | disclosed |
| WO-2010075443-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20100168162-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-07-01 | — | — | US | disclosed |
| US-20100168162-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-07-01 | — | — | US | disclosed |
| US-20090131474-A1 | SCREENING METHODS FOR PROTEIN KINASE B INHIBITORS EMPLOYING VIRTUAL DOCKING APPROACHES AND COMPOUNDS AND COMPOSITIONS DISCOVERED THEREBY | BURNHAM INSTITUTE FOR MEDICAL RESEARCH | 2009-05-21 | — | — | US | disclosed |
| US-20090131474-A1 | SCREENING METHODS FOR PROTEIN KINASE B INHIBITORS EMPLOYING VIRTUAL DOCKING APPROACHES AND COMPOUNDS AND COMPOSITIONS DISCOVERED THEREBY | BURNHAM INSTITUTE FOR MEDICAL RESEARCH | 2009-05-21 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131474-A1 | SCREENING METHODS FOR PROTEIN KINASE B INHIBITORS EMPLOYING VIRTUAL DOCKING APPROACHES AND COMPOUNDS AND COMPOSITIONS DISCOVERED THEREBY | AKT1S1, AKT1, PIK3CA | AKT1 2/4885DUSP3 418/4885NR4A1 2328/4885 |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | AKT1 984/4885DUSP3 282/4885NR4A1 4082/4885 |
| US-20120190707-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | AKT1S1, AKT1, PIK3CA | AKT1 2/4885DUSP3 176/4885NR4A1 3616/4885 |
| US-20230040081-A1 | VACCINIA VIRAL POLYMERASE-MEDIATED VIRAL REPLICATION | POLR1G, POLR1A, POLR1E | AKT1 1877/4885DUSP3 1426/4885NR4A1 4320/4885 |
| US-20100168162-A1 | SELECTIVE INHIBITORS OF AKT AND METHODS OF USING SAME | AKT1S1, AKT1, PIK3CA | AKT1 2/4885DUSP3 411/4885NR4A1 3102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.