Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 1.00 |
| ▸ | CDC25B | P30305 | 1/20 | 1.00 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.75 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.75 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | MAPT | P10636 | 7/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.72 |
| ▸ | POLB | P06746 | 7/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | RECQL | P46063 | 5/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | THRB | P10828 | 2/20 | 0.72 |
| ▸ | APEX1 | P27695 | 2/20 | 0.72 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.72 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.72 |
| ▸ | PLEC | Q15149 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6721110 | 0.89 | AKT1 (0.79) | AKT1CDC25BDUSP3ATAD2NR4A1 | |
| SCHEMBL11942999 | 0.88 | AKT1 (0.79) | AKT1CDC25BDUSP3ATAD2NR4A1 | |
| SCHEMBL6743451 | 0.87 | AKT1 (0.85) | AKT1CDC25BDUSP3ATAD2NR4A1 | |
| SCHEMBL6742448 | 0.87 | AKT1 (0.81) | AKT1CDC25BDUSP3ATAD2NR4A1 | |
| SCHEMBL6742612 | 0.86 | AKT1 (0.88) | AKT1CDC25BDUSP3ATAD2NR4A1 | |
| SCHEMBL6743582 | 0.86 | ATAD2 (1.00) | AKT1CDC25BDUSP3ATAD2NR4A1 | |
| SCHEMBL11942997 | 0.86 | AKT1 (1.00) | AKT1CDC25BDUSP3ATAD2NR4A1 | |
| SCHEMBL4759244 | 0.84 | MEN1 (1.00) | AKT1CDC25BDUSP3ATAD2NR4A1 | |
| SCHEMBL6742607 | 0.81 | AKT1 (0.68) | AKT1CDC25BDUSP3ATAD2NR4A1 | |
| SCHEMBL13864202 | 0.78 | AKT1 (0.86) | AKT1CDC25BDUSP3ATAD2NR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183236-B2 | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-05-22 | — | — | US | disclosed |
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | TYMP, IMPDH1, SAMHD1 | AKT1 964/4885CDC25B 2419/4885DUSP3 1971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.