Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14080989 | 0.89 | POLB (0.59) | ALDH1A1DCTPP1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL13219330 | 0.85 | ALDH1A1 (0.70) | ALDH1A1DCTPP1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL11943534 | 0.84 | ALDH1A1 (0.73) | ALDH1A1DCTPP1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL6030180 | 0.82 | ALDH1A1 (0.66) | ALDH1A1DCTPP1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL11946067 | 0.74 | NPSR1 (0.55) | ALDH1A1DCTPP1MAPTSMN1; SMN2RXFP1 | |
| SCHEMBL11943532 | 0.74 | MAPT (0.43) | ALDH1A1DCTPP1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL13219453 | 0.74 | ALDH1A1 (0.59) | ALDH1A1DCTPP1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL11943537 | 0.73 | POLB (0.64) | ALDH1A1DCTPP1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL11943538 | 0.72 | ALDH1A1 (0.62) | ALDH1A1DCTPP1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL4675758 | 0.71 | CA12 (0.56) | ALDH1A1DCTPP1MAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232274-B2 | Pyridazinone derivatives useful as glucan synthase inhibitors | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-20090170861-A1 | Pyridazinone Derivatives Useful as Glucan Synthase Inhibitors | SCHERING CORPORATION AND ALBANY MOLECULAR RESEARCH, INC. | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170861-A1 | Pyridazinone Derivatives Useful as Glucan Synthase Inhibitors | MAN2A1, GYS2, MANBA | ALDH1A1 2437/4885DCTPP1 625/4885MAPT 2295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.