Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 20/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897814 | 0.85 | HTR2C (0.80) | HTR2C | |
| SCHEMBL1897916 | 0.79 | HTR2C (1.00) | HTR2C | |
| SCHEMBL1900329 | 0.79 | HTR2C (1.00) | HTR2C | |
| SCHEMBL1897865 | 0.76 | HTR2C (0.65) | HTR2C | |
| SCHEMBL1893761 | 0.71 | HTR2C (0.58) | HTR2C | |
| SCHEMBL1894721 | 0.70 | HTR2C (0.60) | HTR2C | |
| SCHEMBL1891770 | 0.70 | HTR2C (0.65) | HTR2C | |
| SCHEMBL1894866 | 0.70 | HTR2C (1.00) | HTR2C | |
| SCHEMBL1891642 | 0.68 | HTR2C (0.54) | HTR2C | |
| SCHEMBL1895830 | 0.68 | HTR2C (0.74) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096520-B2 | Tricyclic ideno-pyrrole derivatives as serotonin receptor modulators | ABT HOLDING COMPANY (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140206739-A1 | TRICYCLIC INDENO-PYRROLE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | ABT HOLDING COMPANY (US) | 2014-07-24 | — | — | US | disclosed |
| US-20120252859-A1 | Tricyclic Indeno-Pyrrole Derivatives as Serotonin Receptor Modulators | ATHERSYS, INC. (US) | 2012-10-04 | — | — | US | disclosed |
| US-8232311-B2 | Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators | ATHERSYS, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-20110172283-A1 | Tricyclic Indeno-Pyrrole Derivatives as Serotonin Receptor Modulators | BENNANI YOUSSEF L | 2011-07-14 | — | — | US | disclosed |
| US-7935830-B2 | Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators | ATHERSYS, INC. (US) | 2011-05-03 | — | — | US | disclosed |
| US-20090239925-A1 | TRICYCLIC INDENO-PYRROLE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | ATHERSYS, INC. | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252859-A1 | Tricyclic Indeno-Pyrrole Derivatives as Serotonin Receptor Modulators | HTR5A, HTR3E, HTR1E | HTR2C 6/4885 |
| US-20110172283-A1 | Tricyclic Indeno-Pyrrole Derivatives as Serotonin Receptor Modulators | HTR5A, HTR3E, HTR1E | HTR2C 6/4885 |
| US-20090239925-A1 | TRICYCLIC INDENO-PYRROLE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | HTR5A, HTR3E, HTR1E | HTR2C 6/4885 |
| US-20140206739-A1 | TRICYCLIC INDENO-PYRROLE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | HTR5A, HTR3E, HTR1E | HTR2C 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.