Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28028689 | 0.85 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1POLBHTTHPGD | |
| SCHEMBL754989 | 0.79 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1POLBHTTHPGD | |
| SCHEMBL334530 | 0.77 | ALDH1A1 (1.00) | SMN1; SMN2ALDH1A1POLBHTTHPGD | |
| SCHEMBL1677059 | 0.77 | ALDH1A1 (0.75) | SMN1; SMN2ALDH1A1POLBHPGDMEN1 | |
| SCHEMBL29522198 | 0.77 | ALDH1A1 (0.75) | SMN1; SMN2ALDH1A1POLBHPGDMEN1 | |
| SCHEMBL11949257 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1POLBHTTHPGD | |
| SCHEMBL8563551 | 0.76 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1POLBHTTHPGD | |
| SCHEMBL29398556 | 0.76 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1POLBHTTHPGD | |
| SCHEMBL3560486 | 0.75 | POLB (0.73) | SMN1; SMN2ALDH1A1POLBHPGDMEN1 | |
| SCHEMBL2858017 | 0.75 | ALDH1A1 (0.73) | SMN1; SMN2ALDH1A1POLBHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232271-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2012-07-31 | — | — | US | disclosed |
| US-20100111900-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | ROCHE PALO ALTO LLC | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100111900-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | POLR2A, EIF2AK2, POLR2B | SMN1; SMN2 3646/4885ALDH1A1 861/4885POLB 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.