Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexchlorpheniramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.81 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.84 |
| ▸ | RAB9A | P51151 | 1/20 | 0.84 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.81 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.81 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.81 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.81 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.81 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.81 |
| ▸ | HTR2A | P28223 | 3/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorpheniramine SCHEMBL14973510 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL30487016 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL27719385 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL4359260 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL33358 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL33357 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL4284232 | 0.99 | LMNA (0.98) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL4284230 | 0.99 | LMNA (0.98) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL28130816 | 0.99 | LMNA (0.98) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL10002622 | 0.99 | LMNA (0.98) | LMNAPMP22BLMNPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3127 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12590272-B2 | Hydrophobic finish car wash compositions comprising an aminosilicone and amphoteric/nonionic surfactant mixture | ENERGIZER AUTO, INC. (US) | 2026-03-31 | — | — | US | claimed |
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| CN-119133438-A | Submicron platy tin phosphide lithium storage and sodium storage material and battery | 温州大学新材料与产业技术研究院 | 2024-12-13 | — | — | CN | claimed |
| CN-119101210-A | High-performance flame-retardant spandex fiber and preparation method thereof | 中原工学院 | 2024-12-10 | — | — | CN | claimed |
| CN-119060292-A | Spandex fiber, preparation method thereof and textile prepared by spandex fiber | 中原工学院 | 2024-12-03 | — | — | CN | claimed |
| CN-119060293-A | Bio-based spandex fiber and preparation method thereof | 中原工学院 | 2024-12-03 | — | — | CN | claimed |
| WO-2024229174-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2024-11-07 | — | — | WO | claimed |
| US-20240295545-A1 | GLIOMA THERAPY | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2024-09-05 | — | — | US | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| EP-0608320-B1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON VICKS INC (US) | 1998-01-28 | — | — | EP | claimed |
| EP-0652774-B1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER | PROCTER & GAMBLE (US) | 1997-05-07 | — | — | EP | claimed |
| US-5614178-A | TRANSDERMAL | THE PROCTER & GAMBLE COMPANY (US) | 1997-03-25 | — | — | US | claimed |
| EP-0608322-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0608320-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| CN-1072863-A | Be used to improve the dermal osmosis system of the reinforcement of medicine localized delivery | RICHARDSON VICKS INC (US) | 1993-06-09 | — | — | CN | claimed |
| WO-1993007902-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| WO-1993007903-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| US-4269835-A | Nasal composition for relieving nasal distress | WHITTLE BARRY J | 1981-05-26 | — | — | US | claimed |