Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorpheniramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.81 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.84 |
| ▸ | RAB9A | P51151 | 1/20 | 0.84 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.81 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.81 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.81 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.81 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.81 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.81 |
| ▸ | HTR2A | P28223 | 3/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorpheniramine SCHEMBL14973510 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL30487016 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Dexchlorpheniramine SCHEMBL119500 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL27719385 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL4359260 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL33357 | 1.00 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL4284232 | 0.99 | LMNA (0.98) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL4284230 | 0.99 | LMNA (0.98) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL28130816 | 0.99 | LMNA (0.98) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL10002622 | 0.99 | LMNA (0.98) | LMNAPMP22BLMNPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10897 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122076970-A | Platinum iridium bimetallic nano-enzyme, preparation method and application thereof in immunochromatography detection | — | 2026-05-26 | — | — | CN | claimed |
| US-12629422-B2 | Agave syrup formulation or suspension for active pharmaceutical agents | GENEXA INC. (US) | 2026-05-19 | — | — | US | claimed |
| EP-4734952-A1 | ORAL TABLET WITH IMPROVED UNIFORMITY OF CONTENT OF ACTIVES | Fertin Pharma A/S (DK) | 2026-05-06 | — | — | EP | claimed |
| US-20260090584-A1 | SYSTEMS AND METHODS FOR ESTIMATING AEROSOLIZATION EMISSION | SCIENTIFIC HORIZONS CONSULTING LLC (US) | 2026-04-02 | — | — | US | claimed |
| US-20260041675-A1 | NASAL COMPOSITION | SATO PHARMACEUTICAL CO., LTD. (JP) | 2026-02-12 | — | — | US | claimed |
| US-20250367139-A1 | COMPOUND HYDROCORTISONE AND NEOMYCIN SULFATE GRANULE AND PREPARATION METHOD THEREOF | HEBEI CHANGTIAN PHARMACEUTICAL CO LTD (CN) | 2025-12-04 | — | — | US | claimed |
| EP-4654949-A1 | USE OF VITAMIN E TPGS AS A TASTE MASKING AGENT FOR BITTER DRUGS | Hyloris Developments SA (BE) | 2025-12-03 | — | — | EP | claimed |
| US-20250332120-A1 | COMPOSITION FOR EXTERNAL PREPARATION | KAO CORPORATION (JP) | 2025-10-30 | — | — | US | claimed |
| US-20250325483-A1 | FLOWPACK WITH COMPOSITION FOR IMPROVED TASTE MASKING OF ACTIVES | FERTIN PHARMA AS (DK) | 2025-10-23 | — | — | US | claimed |
| US-20250312272-A1 | PHARMACEUTICAL FORMULATIONS FOR ORAL ADMINISTRATION AND METHODS OF MAKING AND USING THE SAME | Brunswick Pharma LLC | 2025-10-09 | — | — | US | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |
| US-4576645-A | Whipped gel composition | BLOCK DRUG CO., INC. (US) | 1986-03-18 | — | — | US | claimed |
| EP-0132472-A1 | Medicated products containing a magnesium trisilicate adsorbent with a medicament drug adsorbed thereon | WARNER-LAMBERT COMPANY (US) | 1985-02-13 | — | — | EP | claimed |
| US-4472372-A | Polymeric diffusion matrix containing chlorpheniramine maleate | KEY PHARMACEUTICALS, INC. (US) | 1984-09-18 | — | — | US | claimed |
| US-4455146-A | THERMOPLASTIC ELASTOMERS, OILS OR FATTY ACID, TACKFIER, AND A MEDICINE | HISAMITSU PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | claimed |
| EP-0079545-A1 | Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same | KANEBO, LTD. (JP) | 1983-05-25 | — | — | EP | claimed |
| WO-1982000099-A1 | POLYMERIC DIFFUSION MATRIX FOR ADMINISTRATION OF DRUGS | KEY PHARMA (US) | 1982-01-21 | — | — | WO | claimed |
| US-4278679-A | ANTIHISTAMINE, PREVENTION OF ANTICHOLINERGIC EFFECT | CHROMALLOY AMERICAN CORPORATION (US) | 1981-07-14 | — | — | US | claimed |
| US-4269835-A | Nasal composition for relieving nasal distress | WHITTLE BARRY J | 1981-05-26 | — | — | US | claimed |
| US-4256763-A | ANTIINFLAMMATORY AGENTS, VIRICIDES, PHENOLPHTHALEIN | MCHUGH JOHN E | 1981-03-17 | — | — | US | claimed |