Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorpheniramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.80 |
| ▸ | LMNA | P02545 | 4/20 | 0.98 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.82 |
| ▸ | RAB9A | P51151 | 1/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.80 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.80 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.80 |
| ▸ | HTR2A | P28223 | 3/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorpheniramine SCHEMBL4284230 | 1.00 | LMNA (0.98) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL27719385 | 0.99 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL33357 | 0.99 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL30487016 | 0.99 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL4359260 | 0.99 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL33358 | 0.99 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL14973510 | 0.99 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Dexchlorpheniramine SCHEMBL119500 | 0.99 | LMNA (1.00) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL28130816 | 0.98 | LMNA (0.98) | LMNAPMP22BLMNPSR1TSHR | |
| Chlorpheniramine SCHEMBL10002622 | 0.98 | LMNA (0.98) | LMNAPMP22BLMNPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009152144-A2 | ALL DAY RHINITIC CONDITION TREATMENT REGIMEN | CORNERSTONE THERAPEUTICS, INC. (US) | 2009-12-17 | — | — | WO | disclosed |
| US-20080311196-A1 | All Day Rhinitic Condition Treatment Regimen | CORNERSTONE BIOPHARMA, INC. | 2008-12-18 | — | — | US | disclosed |
| US-20080015241-A1 | All day rhinitic condition treatment regimen | CORNERSTONE BIOPHARMA, INC. | 2008-01-17 | — | — | US | disclosed |