Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | ATF1 | P18846 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11298235 | 0.85 | GAA (0.53) | GAACES2ALDH1A1ASH1LNOTUM | |
| SCHEMBL627496 | 0.82 | GAA (0.56) | GAACES2ALDH1A1MAPTLMNA | |
| SCHEMBL628459 | 0.78 | ALDH1A1 (0.46) | GAACES2ALDH1A1MAPTLMNA | |
| SCHEMBL12128243 | 0.76 | GAA (0.46) | GAACES2ALDH1A1ASH1LCTSL | |
| SCHEMBL12128276 | 0.74 | CTSL (0.47) | GAACES2ALDH1A1ASH1LCTSL | |
| SCHEMBL1198001 | 0.74 | NOTUM (0.53) | GAACES2ALDH1A1ASH1LNOTUM | |
| SCHEMBL3587775 | 0.74 | GAA (0.49) | GAACES2ALDH1A1MAPTASH1L | |
| SCHEMBL11300330 | 0.72 | GAA (0.44) | GAACES2MAPTLMNAPOLB | |
| SCHEMBL16283601 | 0.71 | GAA (0.42) | GAACES2ALDH1A1ASH1LCTSL | |
| SCHEMBL628084 | 0.70 | RXRA (0.43) | GAAALDH1A1ASH1LNOTUMCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012099807-A1 | OLEFIN CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | KARYOPHARM THERAPEUTICS, INC. (US) | 2012-07-26 | — | — | WO | disclosed |