Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | RARA | P10276 | 4/20 | 0.55 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | RARB | P10826 | 3/20 | 0.55 |
| ▸ | RARG | P13631 | 3/20 | 0.55 |
| ▸ | PGR | P06401 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.55 |
| ▸ | BLVRB | P30043 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394957 | 0.91 | MEN1 (0.54) | MEN1KMT2ARARACYP26A1CYP3A4 | |
| SCHEMBL2394731 | 0.87 | KDM4E (0.48) | MEN1KMT2ARARARARBRARG | |
| SCHEMBL2396649 | 0.86 | SMN1; SMN2 (0.47) | MEN1KMT2ARARACYP26A1CYP3A4 | |
| SCHEMBL829589 | 0.85 | RXRA (0.43) | MEN1KMT2ARARACYP26A1CYP3A4 | |
| SCHEMBL11956667 | 0.85 | P4HTM (0.53) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL2397421 | 0.81 | NPC1 (0.45) | MEN1KMT2ARARACYP26A1CYP3A4 | |
| SCHEMBL2394756 | 0.80 | ING2 (0.53) | MEN1KMT2ACYP26A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL829839 | 0.80 | ALDH1A1 (0.46) | MEN1KMT2ARARARARBRARG | |
| SCHEMBL2395760 | 0.79 | HCAR3 (0.53) | RARARARBRARG | |
| SCHEMBL2394353 | 0.79 | NPC1 (0.50) | MEN1KMT2ARARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232300-B2 | Tricyclic amide compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2012-07-31 | — | — | US | disclosed |
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RXRA, RXRB, RXRG | MEN1 3029/4885KMT2A 1560/4885RARA 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.