Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | CLK3 | P49761 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14164230 | 0.86 | HCAR2 (0.64) | HCAR2CLK2CLK3DYRK1AFPR2 | |
| SCHEMBL1881230 | 0.82 | HCAR2 (0.60) | HCAR2POLBKDM4EMAPTCLK2 | |
| SCHEMBL15296847 | 0.81 | HCAR2 (0.50) | HCAR2POLBMAPK14MAPTCLK2 | |
| SCHEMBL27165761 | 0.81 | HCAR2 (0.63) | HCAR2MAPK14CLK2CLK3DYRK1A | |
| SCHEMBL11650054 | 0.80 | USP2 (0.46) | HCAR2POLBPKMMAPK14HPGD | |
| SCHEMBL15296856 | 0.79 | HCAR2 (0.47) | HCAR2RAB9A | |
| SCHEMBL27858708 | 0.79 | HCAR2 (0.72) | HCAR2MAPK14MAPTCLK2CLK3 | |
| SCHEMBL18236191 | 0.78 | RAB9A (0.58) | POLBPKMMAPK14HPGDKDM4E | |
| SCHEMBL294099 | 0.78 | POLB (0.41) | HCAR2POLBPKMMAPK14HPGD | |
| SCHEMBL3401366 | 0.78 | NOS1 (0.42) | HCAR2POLBPKMMAPK14HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260109698-A1 | MALT-1 MODULATORS | EXSCIENTIA AI LIMITED (GB) | 2026-04-23 | — | — | US | disclosed |
| US-20250051327-A1 | MALT-1 MODULATORS | RECURSION PHARMACEUTICALS, INC. | 2025-02-13 | — | — | US | disclosed |
| WO-2024050370-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | 1CBIO, INC. (US) | 2024-03-07 | — | — | WO | disclosed |
| EP-3419974-B1 | PROCESS FOR THE SEPARATION OF ENANTIOMERS OF PIPERAZINE DERIVATIVES | ASCENEURON SA (CH) | 2021-05-05 | — | — | EP | disclosed |
| EP-3419976-B1 | ACID ADDITION SALTS OF PIPERAZINE DERIVATIVES | ASCENEURON SA (CH) | 2021-04-07 | — | — | EP | disclosed |
| WO-2017144635-A1 | PROCESS FOR THE SEPARATION OF ENANTIOMERS OF PIPERAZINE DERIVATIVES | ASCENEURON S. A. (CH) | 2017-08-31 | — | — | WO | disclosed |
| WO-2017144637-A1 | ACID ADDITION SALTS OF PIPERAZINE DERIVATIVES | ASCENEURON S. A. (CH) | 2017-08-31 | — | — | WO | disclosed |
| US-20170022150-A1 | HEPATITIS B ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. | 2017-01-26 | — | — | US | disclosed |
| WO-2017013593-A1 | ISOQUINOLINONE DERIVATIVES AS PARP INHIBITORS | LUPIN LIMITED (IN) | 2017-01-26 | — | — | WO | disclosed |
| US-9102667-B2 | N-arylaminomethylene benzothiophenones for treatment of cardiovascular disease | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2015-08-11 | — | — | US | disclosed |
| US-9102667-B2 | N-arylaminomethylene benzothiophenones for treatment of cardiovascular disease | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2015-08-11 | — | — | US | disclosed |
| US-20130289057-A1 | N-ARYLAMINOMETHYLENE BENZOTHIOPHENONES FOR TREATMENT OF CARDIOVASCULAR DISEASE | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2013-10-31 | — | — | US | disclosed |
| US-20130289057-A1 | N-ARYLAMINOMETHYLENE BENZOTHIOPHENONES FOR TREATMENT OF CARDIOVASCULAR DISEASE | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2013-10-31 | — | — | US | disclosed |
| WO-2012098172-A2 | N-ARYLAMINOMETHYLENE BENZOTHIOPHENONES FOR TREATMENT OF CARDIOVASCULAR DISEASE | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2012-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022150-A1 | HEPATITIS B ANTIVIRAL AGENTS | HAVCR2, ZC3HAV1, SLC10A1 | HCAR2 754/4885POLB 661/4885PKM 3376/4885 |
| US-20130289057-A1 | N-ARYLAMINOMETHYLENE BENZOTHIOPHENONES FOR TREATMENT OF CARDIOVASCULAR DISEASE | TNNT2, NAT1, PAH | HCAR2 2202/4885POLB 2280/4885PKM 487/4885 |
| US-20250051327-A1 | MALT-1 MODULATORS | MALT1, BCL6, BCL9 | HCAR2 3504/4885POLB 4627/4885PKM 3572/4885 |
| US-20260109698-A1 | MALT-1 MODULATORS | MALT1, BCL6, BCL3 | HCAR2 3572/4885POLB 4609/4885PKM 4128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.