Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11948525 | 1.00 | CACNA1C (0.35) | CACNA1CPTGS1ESR1PDE4AXIAP | |
| SCHEMBL13594273 | 0.85 | FAP (0.32) | XIAPFAPKMT2A | |
| SCHEMBL13329882 | 0.84 | ACHE (0.31) | KDM4EMAPTATMACHEMAOB | |
| SCHEMBL13965340 | 0.80 | ADRB2 (0.33) | KDM4EMAPTLMNAKMT2AMEN1 | |
| SCHEMBL13461672 | 0.80 | ESR1 (0.37) | CACNA1CPTGS1ESR1PDE4AKDM4E | |
| SCHEMBL11948533 | 0.80 | ESR1 (0.37) | CACNA1CPTGS1ESR1PDE4AKDM4E | |
| SCHEMBL11948536 | 0.80 | CACNA1C (0.36) | CACNA1CPTGS1ESR1PDE4AFAP | |
| SCHEMBL13461902 | 0.80 | CACNA1C (0.36) | CACNA1CPTGS1ESR1PDE4AFAP | |
| SCHEMBL11957085 | 0.78 | FAP (0.41) | CACNA1CPTGS1ESR1PDE4AFAP | |
| SCHEMBL11948520 | 0.78 | CACNA1C (0.42) | CACNA1CPTGS1ESR1PDE4AFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120296084-A1 | Carbapenem Antibacterials with Gram-Negative Activity and Processes for Their Preparation | FOB SYNTHESIS, INC. (US) | 2012-11-22 | — | — | US | disclosed |
| US-8232268-B2 | Carbapenem antibacterials with gram-negative activity and processes for their preparation | FOB SYNTHESIS, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-7683049-B2 | Carbapenem antibacterials with gram-negative activity and processes for their preparation | FOB SYNTHESIS, INC. (US) | 2010-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120296084-A1 | Carbapenem Antibacterials with Gram-Negative Activity and Processes for Their Preparation | MGAM, GSK3B, GSK3A | CACNA1C 3357/4885PTGS1 2100/4885ESR1 4035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.