Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CFD | P00746 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13862193 | 0.88 | METTL3 (0.47) | METTL3ALDH1A1CFDLMNASMN1; SMN2 | |
| SCHEMBL11948689 | 0.87 | METTL3 (0.64) | METTL3SLC22A12MAPTPKMCFD | |
| SCHEMBL11957090 | 0.86 | METTL3 (0.50) | METTL3SLC22A12PKMCFDTHRB | |
| SCHEMBL11956919 | 0.81 | METTL3 (0.43) | METTL3SLC22A12MAPTPKMCFD | |
| SCHEMBL11948687 | 0.78 | METTL3 (0.69) | METTL3MAPTCFD | |
| SCHEMBL1045841 | 0.78 | METTL3 (0.79) | METTL3MAPTALDH1A1KDM4EPOLB | |
| SCHEMBL1042966 | 0.78 | METTL3 (0.60) | METTL3MAPTALDH1A1CFDLMNA | |
| SCHEMBL1045839 | 0.78 | METTL3 (0.79) | METTL3MAPTALDH1A1KDM4EPOLB | |
| SCHEMBL1042965 | 0.78 | METTL3 (0.60) | METTL3MAPTALDH1A1CFDLMNA | |
| SCHEMBL29874917 | 0.77 | METTL3 (0.68) | METTL3MAPTCFDTHRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232401-B2 | Useful as an anti-HIV agent that particularly shows an anti-HIV action based on an integrase inhibitory activity; for treatment or prophylaxis of AIDS; for example, 6-(2,3-dichlorobenzyl)-1-(2-hydroxyethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | JAPAN TOBACCO INC. (JP) | 2012-07-31 | — | — | US | disclosed |