Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MDM4 | O15151 | 4/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13862215 | 0.86 | ALDH1A1 (0.43) | METTL3SLC22A12PKMMAPTPCSK9 | |
| SCHEMBL11948595 | 0.86 | METTL3 (0.54) | METTL3MAPT | |
| SCHEMBL11948689 | 0.81 | METTL3 (0.64) | METTL3SLC22A12PKMTHRBMAPT | |
| SCHEMBL11956954 | 0.81 | METTL3 (0.49) | METTL3SLC22A12PKMTHRBMAPT | |
| SCHEMBL11957090 | 0.80 | METTL3 (0.50) | METTL3SLC22A12PKMTHRBCFD | |
| SCHEMBL11956944 | 0.79 | SLC22A12 (0.36) | METTL3SLC22A12PKMTHRBMAPT | |
| SCHEMBL1045220 | 0.78 | METTL3 (0.46) | METTL3MAPT | |
| SCHEMBL1045948 | 0.78 | METTL3 (0.54) | METTL3MAPT | |
| SCHEMBL1043831 | 0.76 | METTL3 (0.53) | METTL3MAPT | |
| SCHEMBL1046027 | 0.76 | METTL3 (0.71) | METTL3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232401-B2 | Useful as an anti-HIV agent that particularly shows an anti-HIV action based on an integrase inhibitory activity; for treatment or prophylaxis of AIDS; for example, 6-(2,3-dichlorobenzyl)-1-(2-hydroxyethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | JAPAN TOBACCO INC. (JP) | 2012-07-31 | — | — | US | disclosed |
| US-7531554-B2 | Useful as an anti-HIV agent that particularly shows an anti-HIV action based on an integrase inhibitory activity; for treatment or prophylaxis of AIDS; for example, 6-(2,3-dichlorobenzyl)-1-(2-hydroxyethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | JAPAN TOBACCO INC. (JP) | 2009-05-12 | — | — | US | disclosed |