Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | PRSS12 | P56730 | 5/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11949039 | 0.95 | NR4A2 (0.55) | NR4A2CHEK2HDAC6HDAC3HDAC1 | |
| SCHEMBL11949009 | 0.91 | MMP2 (0.52) | NR4A2CHEK2HDAC6HDAC3HDAC1 | |
| SCHEMBL11949042 | 0.90 | HDAC6 (0.53) | NR4A2CHEK2HDAC6HDAC3HDAC1 | |
| SCHEMBL14046805 | 0.90 | HDAC3 (0.52) | CHEK2HDAC6HDAC3HDAC1HDAC8 | |
| SCHEMBL11949005 | 0.90 | NR4A2 (0.52) | NR4A2CHEK2HDAC6HDAC3HDAC1 | |
| SCHEMBL11949037 | 0.90 | MMP2 (0.55) | NR4A2CHEK2HDAC6HDAC3HDAC1 | |
| SCHEMBL11957168 | 0.90 | HDAC6 (0.59) | CHEK2HDAC6HDAC3HDAC1HDAC8 | |
| SCHEMBL11949041 | 0.89 | PRSS12 (0.56) | NR4A2CHEK2HDAC6PRSS12 | |
| SCHEMBL11949029 | 0.89 | PRSS12 (0.56) | NR4A2CHEK2HDAC6PRSS12 | |
| SCHEMBL11956441 | 0.89 | PRSS12 (0.56) | CHEK2HDAC6HDAC3HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232410-B2 | Benzimidazoles and pharmaceutical compositions thereof | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2012-07-31 | — | — | US | disclosed |
| US-20100256203-A1 | BENZIMIDAZOLES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2010-10-07 | — | — | US | disclosed |
| WO-2008130669-A1 | BENZIMIDAZOLES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256203-A1 | BENZIMIDAZOLES AND PHARMACEUTICAL COMPOSITIONS THEREOF | TBCD, TBC1D5, CFTR | NR4A2 4742/4885CHEK2 3766/4885HDAC6 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.