Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.50 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | MMP8 | P22894 | 3/20 | 0.50 |
| ▸ | MMP13 | P45452 | 3/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | PRSS12 | P56730 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3098570 | 0.93 | MMP2 (0.57) | HDAC3HDAC1HDAC8HDAC6CHEK2 | |
| SCHEMBL3104076 | 0.91 | MMP2 (0.59) | HDAC3HDAC1HDAC8HDAC6CHEK2 | |
| SCHEMBL11957177 | 0.91 | MMP2 (0.51) | HDAC3HDAC1HDAC8HDAC6CHEK2 | |
| SCHEMBL11957222 | 0.90 | NR4A2 (0.50) | HDAC3HDAC1HDAC8HDAC6CHEK2 | |
| SCHEMBL11949005 | 0.90 | NR4A2 (0.52) | HDAC3HDAC1HDAC8HDAC6CHEK2 | |
| SCHEMBL11949007 | 0.90 | MMP2 (0.58) | HDAC3HDAC1HDAC8HDAC6CHEK2 | |
| SCHEMBL3104359 | 0.90 | PRSS12 (0.55) | CHEK2MMP2MMP9MMP8MMP13 | |
| SCHEMBL11957168 | 0.89 | HDAC6 (0.59) | HDAC3HDAC1HDAC8HDAC6CHEK2 | |
| SCHEMBL3099694 | 0.89 | HDAC6 (0.56) | HDAC3HDAC1HDAC8HDAC6CHEK2 | |
| SCHEMBL11956441 | 0.89 | PRSS12 (0.56) | HDAC3HDAC1HDAC8HDAC6CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130669-A1 | BENZIMIDAZOLES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2008-10-30 | — | — | WO | disclosed |