Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 3/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22647484 | 0.86 | CYP1A2 (0.46) | CYP1A2XDHULK1GABRPGABRD | |
| SCHEMBL11965472 | 0.84 | GAA (0.47) | CYP1A2XDHULK1KDM4EALDH1A1 | |
| SCHEMBL1504255 | 0.84 | HRH4 (0.57) | CYP1A2XDHULK1KDM4EALDH1A1 | |
| SCHEMBL19332395 | 0.80 | ULK1 (0.50) | CYP1A2XDHULK1KDM4EFLT3 | |
| SCHEMBL915460 | 0.78 | HRH4 (0.55) | CYP1A2XDHULK1FTOKDM4E | |
| SCHEMBL30310659 | 0.78 | HRH4 (0.55) | CYP1A2XDHULK1FTOKDM4E | |
| SCHEMBL30310454 | 0.78 | DAO (0.52) | CYP1A2XDHULK1KDM4EALDH1A1 | |
| SCHEMBL19332317 | 0.78 | DAO (0.52) | CYP1A2XDHULK1KDM4EALDH1A1 | |
| SCHEMBL22620744 | 0.78 | CYP1A2 (0.44) | CYP1A2XDHULK1KDM4EALDH1A1 | |
| SCHEMBL23049700 | 0.77 | ULK1 (0.48) | CYP1A2XDHULK1KIF11GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778893-B2 | (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol metabolites | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-07-15 | — | — | US | disclosed |
| US-20120196814-A1 | (R)-1-(4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY)PROPAN-2-OL METABOLITES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-08-02 | — | — | US | disclosed |
| WO-2011044019-A1 | (R)-1-(4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY)PROPAN-2-OL METABOLITES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196814-A1 | (R)-1-(4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY)PROPAN-2-OL METABOLITES | CYP11B1, CYP11B2, CYP4B1 | CYP1A2 9/4885XDH 1868/4885ULK1 2731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.