Sugi Predict

Sugi Predict / Compounds / SCHEMBL11975

SCHEMBL11975

SCHEMBL11975

COc1c(F)cc(-c2n[nH]c3ncnc(N)c23)cc1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3CB P42338 11/20 0.39
▸ PIK3CG P48736 11/20 0.39
▸ PRKDC P78527 11/20 0.39
▸ PIK3CD O00329 11/20 0.39
▸ MTOR P42345 10/20 0.39
▸ PIK3CA P42336 10/20 0.39
▸ ABL1 P00519 9/20 0.39
▸ EGFR P00533 9/20 0.39
▸ HCK P08631 9/20 0.39
▸ SRC P12931 9/20 0.39
▸ KDR P35968 9/20 0.39
▸ EPHB4 P54760 9/20 0.39
▸ PI4KB Q9UBF8 7/20 0.39
▸ BRD4 O60885 1/20 0.36
▸ PDE5A O76074 1/20 0.35
▸ PDGFRB P09619 1/20 0.35
▸ PDGFRA P16234 1/20 0.35
▸ KIT P10721 1/20 0.34
▸ SGK1 O00141 1/20 0.33
▸ MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19414291 0.85 SRC (0.40) PIK3CBPIK3CGPRKDCPIK3CDMTOR
SCHEMBL10811 0.83 SRC (0.57) PIK3CBPIK3CGPRKDCPIK3CDMTOR
SCHEMBL11306 0.83 SRC (0.47) PIK3CBPIK3CGPRKDCPIK3CDMTOR
SCHEMBL19414400 0.82 CYP1A1 (0.47) PIK3CBPIK3CGPRKDCPIK3CDMTOR
SCHEMBL20093476 0.82 VRK1 (0.41) PIK3CBPIK3CGPRKDCPIK3CDMTOR
SCHEMBL152637 0.82 PIK3CD (0.49) PIK3CBPIK3CGPRKDCPIK3CDMTOR
SCHEMBL23917192 0.81 MAP4K4 (0.38) PIK3CBPIK3CGPRKDCPIK3CDMTOR
SCHEMBL16655157 0.78 PIK3CD (0.47) PIK3CBPIK3CGPRKDCPIK3CDMTOR
SCHEMBL11670 0.76 EGFR (0.41) PIK3CBPIK3CGPRKDCPIK3CDMTOR
SCHEMBL149528 0.76 KDR (0.52) PIK3CBPIK3CGPRKDCPIK3CDMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240360095-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS AG (CH) 2024-10-31 — — US disclosed
US-11858907-B2 Kinase modulators RHIZEN PHARMACEUTICALS AG (CH) 2024-01-02 — — US disclosed
US-11858907-B2 Kinase modulators RHIZEN PHARMACEUTICALS AG (CH) 2024-01-02 — — US disclosed
US-20210401840-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS AG (CH) 2021-12-30 — — US disclosed
US-11020399-B2 Intermediates useful in the synthesis of compounds as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2021-06-01 — — US disclosed
US-20200239427-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS AG (CH) 2020-07-30 — — US disclosed
US-10442783-B2 2,3-disubstituted chromen-4-one compounds as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2019-10-15 — — US disclosed
US-20190282581-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS AG (CH) 2019-09-19 — — US disclosed
US-10322130-B2 Substituted chromenones as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2019-06-18 — — US disclosed
US-20190105324-A9 SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS AG (CH) 2019-04-11 — — US disclosed
US-9421209-B2 Kinase modulators RHIZEN PHARMACEUTICALS SA (CH) 2016-08-23 — — US disclosed
EP-3050876-A2 KINASE MODULATORS Rhizen Pharmaceuticals S.A. (CH) 2016-08-03 — — EP disclosed
US-20150174131-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS AG (CH) 2015-06-25 — — US disclosed
US-9018375-B2 Substituted chromenes as kinase modulators RHIZEN PHARMACEUTICALS SA (CH) 2015-04-28 — — US disclosed
US-20140080827-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS SA (CH) 2014-03-20 — — US disclosed
US-8642607-B2 4H-chromen-4-one compounds as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2014-02-04 — — US disclosed
EP-2496567-A2 NOVEL BENZOPYRAN KINASE MODULATORS Rhizen Pharmaceuticals S.A. (CH) 2012-09-12 — — EP disclosed
US-20120059001-A1 NOVEL KINASE MODULATORS INCOZEN THERAPEUTICS PVT. LTD. (IN) 2012-03-08 — — US disclosed
US-20110118257-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS SA (CH) 2011-05-19 — — US disclosed
WO-2011055215-A2 NOVEL KINASE MODULATORS INCOZEN THERAPEUTICS PVT. LTD. (IN) 2011-05-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10442783-B2 2,3-disubstituted chromen-4-one compounds as modulators of protein kinases PIK3CB, PIK3CD, PDPK1 PIK3CB 1/4885PIK3CG 15/4885PRKDC 244/4885
US-20210401840-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB PIK3CB 23/4885PIK3CG 77/4885PRKDC 141/4885
US-20150174131-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB PIK3CB 33/4885PIK3CG 99/4885PRKDC 164/4885
US-11020399-B2 Intermediates useful in the synthesis of compounds as modulators of protein kinases MAP4K2, MAP3K20, MAP3K1 PIK3CB 248/4885PIK3CG 406/4885PRKDC 111/4885
US-20240360095-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB PIK3CB 33/4885PIK3CG 99/4885PRKDC 164/4885
US-20190105324-A9 SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKAR2B PIK3CB 83/4885PIK3CG 128/4885PRKDC 178/4885
US-20140080827-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB PIK3CB 33/4885PIK3CG 99/4885PRKDC 164/4885
US-20190282581-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB PIK3CB 23/4885PIK3CG 77/4885PRKDC 141/4885
US-20110118257-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB PIK3CB 33/4885PIK3CG 99/4885PRKDC 164/4885
US-20200239427-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB PIK3CB 33/4885PIK3CG 99/4885PRKDC 164/4885
US-10322130-B2 Substituted chromenones as modulators of protein kinases MAP3K1, CSNK1A1, MAP3K2 PIK3CB 181/4885PIK3CG 194/4885PRKDC 325/4885
US-11858907-B2 Kinase modulators RPS6KA1, RPS6KA2, PRKAR2A PIK3CB 102/4885PIK3CG 126/4885PRKDC 253/4885
US-20120059001-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB PIK3CB 33/4885PIK3CG 99/4885PRKDC 164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.