Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 13/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.47 |
| ▸ | ABL1 | P00519 | 10/20 | 0.47 |
| ▸ | EGFR | P00533 | 9/20 | 0.47 |
| ▸ | HCK | P08631 | 9/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.47 |
| ▸ | MTOR | P42345 | 9/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.47 |
| ▸ | PRKDC | P78527 | 9/20 | 0.47 |
| ▸ | KDR | P35968 | 8/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10811 | 0.90 | SRC (0.57) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL149180 | 0.88 | PIK3CD (0.55) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL217790 | 0.88 | ABL1 (0.49) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL13717800 | 0.87 | CSNK1E (0.45) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL13717774 | 0.85 | PIK3CD (0.41) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL19414295 | 0.85 | SRC (0.47) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL22075531 | 0.83 | ALDH1A1 (0.40) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL22692856 | 0.83 | ERBB2 (0.50) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL11975 | 0.83 | PIK3CB (0.39) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL16665685 | 0.83 | PIK3CD (0.67) | SRCPIK3CDABL1EGFRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113968861-B | Compound with PI3K delta/BTK double-target-point activity and preparation method and application thereof | 杭州医学院 | 2022-10-21 | — | — | CN | claimed |
| CN-113968861-A | Compound with PI3K delta/BTK double-target-point activity and preparation method and application thereof | 杭州医学院 | 2022-01-25 | — | — | CN | claimed |
| US-20110118257-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS SA (CH) | 2011-05-19 | — | — | US | claimed |
| US-12221448-B2 | Selective PI3Kδ inhibitor and use thereof | Tarapeutics Science Inc. (CN) | 2025-02-11 | — | — | US | disclosed |
| US-20240360095-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS AG (CH) | 2024-10-31 | — | — | US | disclosed |
| EP-3892619-B1 | SELECTIVE PHOSPHATIDYLINOSITOL 3 KINASE (PI3K) INHIBITORS AND USE THEREOF | TARAPEUTICS SCIENCE INC (CN) | 2024-06-26 | — | — | EP | disclosed |
| EP-3892619-B1 | SELECTIVE PHOSPHATIDYLINOSITOL 3 KINASE (PI3K) INHIBITORS AND USE THEREOF | TARAPEUTICS SCIENCE INC (CN) | 2024-06-26 | — | — | EP | disclosed |
| US-11858907-B2 | Kinase modulators | RHIZEN PHARMACEUTICALS AG (CH) | 2024-01-02 | — | — | US | disclosed |
| CN-111269231-B | Selective PI3K delta inhibitor and application thereof | 安徽中科拓苒药物科学研究有限公司 | 2023-06-09 | — | — | CN | disclosed |
| CN-113968861-B | Compound with PI3K delta/BTK double-target-point activity and preparation method and application thereof | 杭州医学院 | 2022-10-21 | — | — | CN | disclosed |
| US-20220251092-A1 | CASEIN KINASE 1EPSILON INHIBITOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Hangzhou Healzen Therapeutics Co., Ltd. (CN) | 2022-08-11 | — | — | US | disclosed |
| US-20160318890-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS AG (CH) | 2016-11-03 | — | — | US | disclosed |
| US-9421209-B2 | Kinase modulators | RHIZEN PHARMACEUTICALS SA (CH) | 2016-08-23 | — | — | US | disclosed |
| EP-3050876-A2 | KINASE MODULATORS | Rhizen Pharmaceuticals S.A. (CH) | 2016-08-03 | — | — | EP | disclosed |
| US-20150174131-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS AG (CH) | 2015-06-25 | — | — | US | disclosed |
| US-9018375-B2 | Substituted chromenes as kinase modulators | RHIZEN PHARMACEUTICALS SA (CH) | 2015-04-28 | — | — | US | disclosed |
| US-20140080827-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS SA (CH) | 2014-03-20 | — | — | US | disclosed |
| US-8642607-B2 | 4H-chromen-4-one compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2014-02-04 | — | — | US | disclosed |
| US-20120059001-A1 | NOVEL KINASE MODULATORS | INCOZEN THERAPEUTICS PVT. LTD. (IN) | 2012-03-08 | — | — | US | disclosed |
| US-20110118257-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS SA (CH) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150174131-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | SRC 314/4885PIK3CD 70/4885ABL1 465/4885 |
| US-20240360095-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | SRC 314/4885PIK3CD 70/4885ABL1 465/4885 |
| US-20140080827-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | SRC 314/4885PIK3CD 70/4885ABL1 465/4885 |
| US-20110118257-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | SRC 314/4885PIK3CD 70/4885ABL1 465/4885 |
| US-11858907-B2 | Kinase modulators | RPS6KA1, RPS6KA2, PRKAR2A | SRC 110/4885PIK3CD 103/4885ABL1 258/4885 |
| US-20160318890-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | SRC 314/4885PIK3CD 70/4885ABL1 465/4885 |
| US-12221448-B2 | Selective PI3Kδ inhibitor and use thereof | PIK3CA, PIK3CD, PIK3R2 | SRC 99/4885PIK3CD 2/4885ABL1 199/4885 |
| US-20120059001-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | SRC 314/4885PIK3CD 70/4885ABL1 465/4885 |
| US-20220251092-A1 | CASEIN KINASE 1EPSILON INHIBITOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | CSNK1E, CSNK1A1, CSNK1G1 | SRC 100/4885PIK3CD 439/4885ABL1 402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.