Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.65 |
| ▸ | HTR3A | P46098 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM6A | O15550 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11979725 | 0.88 | TOP2A (0.63) | TOP2AHTR3AKCNH2KDM6BKDM6A | |
| SCHEMBL2959863 | 0.86 | TOP2A (0.70) | TOP2AHTR3AKCNH2KDM6BKDM6A | |
| SCHEMBL12807869 | 0.84 | TOP2A (0.67) | TOP2AHTR3AKCNH2KDM6BKDM6A | |
| SCHEMBL14367754 | 0.84 | TOP2A (0.75) | TOP2AHTR3AKCNH2KDM6BKDM6A | |
| SCHEMBL12807870 | 0.82 | TOP2A (0.65) | TOP2AHTR3AKCNH2KDM6BKDM6A | |
| SCHEMBL15996408 | 0.81 | TOP2A (0.70) | TOP2AHTR3AKCNH2CYP3A4CREBBP | |
| SCHEMBL5619653 | 0.81 | TOP2A (0.95) | TOP2AHTR3AKCNH2CYP3A4ALDH1A1 | |
| SCHEMBL11979724 | 0.79 | TOP2A (1.00) | TOP2AHTR3AKCNH2CYP3A4ALDH1A1 | |
| SCHEMBL29354263 | 0.79 | TOP2A (1.00) | TOP2AHTR3AKCNH2CYP3A4ALDH1A1 | |
| SCHEMBL9472720 | 0.78 | TOP2A (0.77) | TOP2AKDM6BKDM6ACASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822515-B2 | Heterocyclic benzoxazole compositions as inhibitors of hepatitis C virus | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2014-09-02 | — | — | US | disclosed |
| US-20120208856-A1 | Heterocyclic Benzoxazole Compositions as Inhibitors of Hepatitis C Virus | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208856-A1 | Heterocyclic Benzoxazole Compositions as Inhibitors of Hepatitis C Virus | HAVCR2, CYP3A7, CYP2C9 | TOP2A 2515/4885HTR3A 3280/4885KCNH2 1890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.