Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14367754 | 0.97 | TOP2A (0.75) | TOP2AALDH1A1LMNAALOX12KDM4E | |
| SCHEMBL12807869 | 0.89 | TOP2A (0.67) | TOP2AALDH1A1KDM4EHPGDKDM6B | |
| SCHEMBL11979720 | 0.86 | TOP2A (0.65) | TOP2AALDH1A1LMNAALOX12MAOA | |
| SCHEMBL12807870 | 0.86 | TOP2A (0.65) | TOP2AALDH1A1LMNAALOX12KDM6B | |
| SCHEMBL15996408 | 0.85 | TOP2A (0.70) | TOP2AALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL5619653 | 0.85 | TOP2A (0.95) | TOP2AALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL11979725 | 0.85 | TOP2A (0.63) | TOP2AALDH1A1LMNAALOX12MAOA | |
| SCHEMBL121763 | 0.84 | TOP2A (0.55) | TOP2AALDH1A1HPGDSMN1; SMN2MAOA | |
| SCHEMBL2962341 | 0.84 | TOP2A (0.55) | TOP2AALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL120317 | 0.84 | TOP2A (0.55) | TOP2AKDM4EHPGDSMN1; SMN2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11421223-B2 | Processes and host cells for genome, pathway, and biomolecular engineering | ENEVOLV, INC. (US) | 2022-08-23 | — | — | US | disclosed |
| US-20190309289-A1 | PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING | ENEVOLV, INC. | 2019-10-10 | — | — | US | disclosed |
| US-10370654-B2 | Processes and host cells for genome, pathway, and biomolecular engineering | ENEVOLV, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180320170-A1 | PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING | ENEVOLV, INC. | 2018-11-08 | — | — | US | disclosed |
| US-9944925-B2 | Processes and host cells for genome, pathway, and biomolecular engineering | ENEVOLV, INC. | 2018-04-17 | — | — | US | disclosed |
| US-20160186168-A1 | PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING | ENEVOLV, INC. | 2016-06-30 | — | — | US | disclosed |
| EP-3027754-A1 | PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING | enEvolv, Inc. (US) | 2016-06-08 | — | — | EP | disclosed |
| WO-2015017866-A1 | PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING | ENEVOLV, INC. (US) | 2015-02-05 | — | — | WO | disclosed |
| US-8822515-B2 | Heterocyclic benzoxazole compositions as inhibitors of hepatitis C virus | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2014-09-02 | — | — | US | disclosed |
| US-8822515-B2 | Heterocyclic benzoxazole compositions as inhibitors of hepatitis C virus | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2014-09-02 | — | — | US | disclosed |
| US-20120208856-A1 | Heterocyclic Benzoxazole Compositions as Inhibitors of Hepatitis C Virus | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY | 2012-08-16 | — | — | US | disclosed |
| US-20120208856-A1 | Heterocyclic Benzoxazole Compositions as Inhibitors of Hepatitis C Virus | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY | 2012-08-16 | — | — | US | disclosed |
| WO-2011047390-A2 | HETEROCYCLIC BENZOXAZOLE COMPOSITIONS AS INHIBITORS OF HEPATITIS C VIRUS | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2011-04-21 | — | — | WO | disclosed |
| US-7781430-B2 | Benzoxazole carboxamides for treating CINV and IBS-D | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-20080108609-A1 | Benzoxazole Carboxamides For Treating CINV and IBS-D | AMR TECHNOLOGY, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| CN-101160307-A | Benzoxazole carboxamides for the treatment of CINV and IBS-D | AMR TECHNOLOGY INC (US) | 2008-04-09 | — | — | CN | disclosed |
| US-7307094-B2 | Benzoxazole carboxamides for treating CINV and IBS-D | AMR TECHNOLOGY, INC. (US) | 2007-12-11 | — | — | US | disclosed |
| EP-1853597-A1 | BENZOXAZOLE CARBOXAMIDES FOR TREATING CINV AND IBS-D | AMR Technology, Inc. (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006089100-A1 | BENZOXAZOLE CARBOXAMIDES FOR TREATING CINV AND IBS-D | AMR TECHNOLOGY, INC. (US) | 2006-08-24 | — | — | WO | disclosed |
| US-20060183769-A1 | Benzoxazole carboxamides for treating CINV and IBS-D | AMR TECHNOLOGY, INC. (US) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108609-A1 | Benzoxazole Carboxamides For Treating CINV and IBS-D | HTR3E, BRS3, HTR3A | TOP2A 1421/4885ALDH1A1 3208/4885LMNA 2708/4885 |
| US-20060183769-A1 | Benzoxazole carboxamides for treating CINV and IBS-D | HTR3E, BRS3, HTR3A | TOP2A 1421/4885ALDH1A1 3208/4885LMNA 2708/4885 |
| US-20120208856-A1 | Heterocyclic Benzoxazole Compositions as Inhibitors of Hepatitis C Virus | HAVCR2, CYP3A7, CYP2C9 | TOP2A 2515/4885ALDH1A1 749/4885LMNA 707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.