Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2959863 | 0.97 | TOP2A (0.70) | TOP2AALDH1A1MAOAIDO1MAOB | |
| SCHEMBL12807869 | 0.86 | TOP2A (0.67) | TOP2AALDH1A1KDM4EHPGDKDM6B | |
| SCHEMBL29354263 | 0.86 | TOP2A (1.00) | TOP2AALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL11979724 | 0.86 | TOP2A (1.00) | TOP2AALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL14367752 | 0.85 | TOP2A (0.60) | TOP2AALDH1A1MAOAIDO1MAOB | |
| SCHEMBL29885350 | 0.85 | TOP2A (0.60) | TOP2AALDH1A1MAOAIDO1MAOB | |
| SCHEMBL12807870 | 0.84 | TOP2A (0.65) | TOP2AALDH1A1LMNAALOX12MEN1 | |
| SCHEMBL11979720 | 0.84 | TOP2A (0.65) | TOP2AALDH1A1MAOAIDO1MAOB | |
| SCHEMBL9472720 | 0.84 | TOP2A (0.77) | TOP2AALDH1A1KDM4EHPGDKDM6B | |
| SCHEMBL5619653 | 0.83 | TOP2A (0.95) | TOP2AALDH1A1LMNAKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294643-B2 | UK-1 analogues: methods of preparation and use | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-11-13 | — | — | US | disclosed |
| US-7294643-B2 | UK-1 analogues: methods of preparation and use | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-11-13 | — | — | US | disclosed |