Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.58 |
| ▸ | CTSL | P07711 | 5/20 | 0.58 |
| ▸ | CTSK | P43235 | 3/20 | 0.51 |
| ▸ | CTSB | P07858 | 3/20 | 0.51 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.48 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 3/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12062829 | 0.87 | CTSL (0.56) | CTSSCTSLCTSKCASP1SIRT2 | |
| SCHEMBL4726420 | 0.87 | CTSL (0.56) | CTSSCTSLCTSKCASP1SIRT2 | |
| SCHEMBL8298775 | 0.87 | CTSL (0.56) | CTSSCTSLCTSKCASP1SIRT2 | |
| SCHEMBL8276699 | 0.85 | SIRT2 (0.55) | CTSSCTSLCTSKCASP1SIRT2 | |
| SCHEMBL2118680 | 0.85 | CTSL (0.77) | CTSSCTSLCTSKCTSBTLR2 | |
| Water SCHEMBL4982047 | 0.85 | CTSL (0.57) | CTSSCTSLCTSKCTSBCASP1 | |
| SCHEMBL14346835 | 0.84 | ITGB3 (0.59) | CTSSCTSLCTSKCTSBCAPN1 | |
| SCHEMBL8402651 | 0.84 | ITGB3 (0.59) | CTSSCTSLCTSKCTSBCAPN1 | |
| SCHEMBL28707519 | 0.84 | CASP1 (0.60) | CTSSCTSLCTSKCTSBCASP1 | |
| SCHEMBL28707521 | 0.84 | CASP1 (0.60) | CTSSCTSLCTSKCTSBCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2484688-A1 | PEPTIDE EPOXYKETONES FOR PROTEASOME INHIBITION | Onyx Therapeutics, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |