Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.74 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1200311 | 0.89 | KCNH2 (0.66) | KCNH2SLC10A6MAPTLMNATSHR | |
| SCHEMBL12395476 | 0.86 | SLC10A6 (0.69) | KCNH2SLC10A6MAPTLMNATSHR | |
| SCHEMBL7531342 | 0.85 | ACLY (0.54) | KCNH2SLC10A6LMNATSHRHPGD | |
| SCHEMBL1199270 | 0.85 | KCNH2 (1.00) | KCNH2SLC10A6MAPTLMNATSHR | |
| SCHEMBL1200348 | 0.85 | SMN1; SMN2 (0.69) | KCNH2SLC10A6MAPTLMNATSHR | |
| SCHEMBL1200198 | 0.85 | SLC10A6 (0.67) | KCNH2SLC10A6MAPTLMNATSHR | |
| SCHEMBL1199591 | 0.84 | KCNH2 (0.80) | KCNH2SLC10A6MAPTLMNATSHR | |
| SCHEMBL1200118 | 0.83 | KCNH2 (0.79) | KCNH2SLC10A6MAPTLMNATSHR | |
| SCHEMBL2749565 | 0.82 | KCNH2 (0.77) | KCNH2SLC10A6MAPTLMNATSHR | |
| SCHEMBL2748962 | 0.81 | KCNH2 (0.69) | KCNH2SLC10A6MAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028469-A1 | Thiphene-2-Carboxamide Derivatives As Modulators of CCR9 Receptor | ANDERSON ERIC C | 2011-02-03 | — | — | US | disclosed |
| US-20110028469-A1 | Thiphene-2-Carboxamide Derivatives As Modulators of CCR9 Receptor | ANDERSON ERIC C | 2011-02-03 | — | — | US | disclosed |
| US-20110028469-A1 | Thiphene-2-Carboxamide Derivatives As Modulators of CCR9 Receptor | ANDERSON ERIC C | 2011-02-03 | — | — | US | disclosed |
| EP-2207772-A1 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES AS MODULATORS OF CCR9 RECEPTOR | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-07-21 | — | — | EP | disclosed |
| WO-2009044311-A1 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES AS MODULATORS OF CCR9 RECEPTOR | ENCYSIVE PHARMACEUTICALS INC. (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028469-A1 | Thiphene-2-Carboxamide Derivatives As Modulators of CCR9 Receptor | CCR9, CCR1, CCR10 | KCNH2 4625/4885SLC10A6 2880/4885MAPT 3701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.