Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 9/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PTPRF | P10586 | 1/20 | 0.40 |
| ▸ | PTPRA | P18433 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971665 | 0.91 | PTPN1 (0.45) | LMNAPTGER4PTPN1PPARGPPARA | |
| SCHEMBL3976050 | 0.84 | LMNA (0.46) | LMNAPTGER4PTPN1PPARGPPARA | |
| SCHEMBL11993053 | 0.80 | NPC1 (0.55) | PPARGPPARA | |
| SCHEMBL6904181 | 0.79 | PTPN1 (0.38) | LMNAPTGER4PTPN1PPARGPPARA | |
| SCHEMBL3969193 | 0.79 | PPARG (0.45) | PPARGPPARAMAPT | |
| SCHEMBL3971631 | 0.79 | PPARG (0.53) | PPARGPPARA | |
| SCHEMBL13418750 | 0.78 | PTPN1 (0.63) | LMNAPTGER4PTPN1PPARGPPARA | |
| SCHEMBL11993106 | 0.77 | PPARG (0.46) | PPARGPPARANPSR1ALDH1A1KDM4E | |
| SCHEMBL11992997 | 0.76 | PPARG (0.43) | PPARGPPARA | |
| Pemaglitazar SCHEMBL29908544 | 0.76 | PPARG (0.56) | PTPN1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412326-B1 | BUTYRIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-08-22 | — | — | EP | disclosed |
| US-7491747-B2 | 4-(Arylthio)- or (4-heteroarylthio)butyric acid derivatives that may be used in the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2009-02-17 | — | — | US | disclosed |
| US-7491747-B2 | 4-(Arylthio)- or (4-heteroarylthio)butyric acid derivatives that may be used in the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2009-02-17 | — | — | US | disclosed |