Sugi Predict

Sugi Predict / Compounds / SCHEMBL11997494

SCHEMBL11997494

SCHEMBL11997494

CCCCCO[C@@H]1OC(COS(=O)(=O)O)[C@@H](O[C@H]2C[C@H](O)[C@@H](O[C@@H]3OC(COS(=O)(=O)O)[C@@H](O[C@H]4C[C@H](O)[C@@H](O[C@@H]5OC(COS(=O)(=O)O)[C@@H](O[C@H]6C[C@H](O)[C@@H](O[C@@H]7OC(COS(=O)(=O)O)[C@@H](O[C@H]8C[C@H](O)[C@H](O)CO8)[C@H](O)C7NC(=O)CCC)CO6)[C@H](O)C5NC(=O)CCC)CO4)[C@H](O)C3NC(=O)CCC)CO2)[C@H](O)C1NC(=O)CCC

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ VEGFA P15692 5/20 0.43
▸ BMP2 P12643 2/20 0.43
▸ CXCL12 P48061 2/20 0.43
▸ SHH Q15465 2/20 0.43
▸ IFNG P01579 1/20 0.40
▸ PF4 P02776 1/20 0.40
▸ CCL2 P13500 1/20 0.40
▸ SELP P16109 1/20 0.40
▸ BMP6 P22004 1/20 0.40
▸ CCL11 P51671 1/20 0.40
▸ WNT3A P56704 1/20 0.40
▸ SELPLG Q14242 1/20 0.40
▸ MAPK1 P28482 1/20 0.37
▸ BDNF P23560 3/20 0.36
▸ PTN P21246 2/20 0.36
▸ MDK P21741 2/20 0.36
▸ HPSE Q9Y251 10/20 0.35
▸ FGF1 P05230 6/20 0.35
▸ FGF2 P09038 6/20 0.35
▸ LGALS8 O00214 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11997495 0.97 VEGFA (0.43) VEGFABMP2CXCL12SHHIFNG
SCHEMBL11997493 0.93 VEGFA (0.50) VEGFABMP2CXCL12SHHIFNG
SCHEMBL11997497 0.92 VEGFA (0.49) VEGFABMP2CXCL12SHHIFNG
SCHEMBL11997496 0.89 VEGFA (0.41) VEGFABMP2CXCL12SHHIFNG
SCHEMBL11997506 0.88 LGALS3 (0.35) VEGFABMP2CXCL12SHHIFNG
SCHEMBL11997507 0.87 SELL (0.32) VEGFABMP2CXCL12SHHSELP
SCHEMBL11997509 0.86 BMP2 (0.33) VEGFABMP2CXCL12SHHIFNG
SCHEMBL11997510 0.86 CA1 (0.33) VEGFABMP2CXCL12SHHBDNF
SCHEMBL11997498 0.81 BDNF (0.42) VEGFABMP2CXCL12SHHIFNG
SCHEMBL11997499 0.81 F10 (0.40) VEGFABMP2CXCL12SHHIFNG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012413-B2 FGF receptor-activating N-acyl octasaccharides, preparation thereof, and therapeutic use thereof SANOFI (FR) 2015-04-21 — — US disclosed
US-20120214754-A1 FGF RECEPTOR-ACTIVATING N-ACYL OCTASACCHARIDES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF SANOFI (FR) 2012-08-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120214754-A1 FGF RECEPTOR-ACTIVATING N-ACYL OCTASACCHARIDES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF FGFR1, FGF2, FGFR3 VEGFA 202/4885BMP2 245/4885CXCL12 343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback