Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.36 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.36 |
| ▸ | TTBK1 | Q5TCY1 | 9/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.31 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.30 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12001555 | 0.91 | METAP2 (0.35) | TTBK1PDK2PDE4DFFAR4MAP3K14 | |
| SCHEMBL12001804 | 0.91 | METAP2 (0.35) | TTBK1PDK2PDE4DFFAR4MAP3K14 | |
| SCHEMBL12001560 | 0.90 | TTBK1 (0.38) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12001653 | 0.90 | TTBK1 (0.38) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12001704 | 0.90 | TTBK1 (0.38) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12525048 | 0.88 | TTBK1 (0.35) | TTBK1ROCK1PDK2PDE4DFFAR4 | |
| SCHEMBL12001492 | 0.88 | TTBK1 (0.35) | TTBK1ROCK1PDK2PDE4DFFAR4 | |
| SCHEMBL12001547 | 0.87 | TTBK1 (0.35) | TTBK1ROCK1PDK2PDE4DFFAR4 | |
| SCHEMBL12001491 | 0.87 | TTBK1 (0.34) | TTBK1 | |
| SCHEMBL12001643 | 0.86 | HRH4 (0.38) | TTBK1ROCK1MAP3K14PAK4PIKFYVE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | GENENTECH, INC. (US) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | NFKB1, NFRKB, NFKBIA | PIK3CD 3675/4885PIK3R2 2086/4885PIK3CA 2818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.