Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12001555 | 1.00 | METAP2 (0.35) | METAP2NPC1HSD17B10TTBK1GRM4 | |
| SCHEMBL12001492 | 0.92 | TTBK1 (0.35) | TTBK1PDK2PDE4DFFAR4PAK4 | |
| SCHEMBL12525048 | 0.92 | TTBK1 (0.35) | TTBK1PDK2PDE4DFFAR4PAK4 | |
| SCHEMBL12001554 | 0.91 | PIK3CD (0.36) | TTBK1PDK2PDE4DFFAR4PAK4 | |
| SCHEMBL12001547 | 0.91 | TTBK1 (0.35) | TTBK1PDK2PDE4DFFAR4PAK4 | |
| SCHEMBL12001564 | 0.89 | PDK2 (0.36) | TTBK1PDK2PDE4DFFAR4PAK4 | |
| SCHEMBL12001653 | 0.88 | TTBK1 (0.38) | NPC1HSD17B10TTBK1ALDH1A1ALOX5AP | |
| SCHEMBL12001704 | 0.88 | TTBK1 (0.38) | NPC1HSD17B10TTBK1ALDH1A1ALOX5AP | |
| SCHEMBL12001560 | 0.88 | TTBK1 (0.38) | NPC1HSD17B10TTBK1ALDH1A1ALOX5AP | |
| SCHEMBL11970422 | 0.87 | MAP3K14 (0.44) | TTBK1PDK2PAK4PIKFYVEMAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | GENENTECH, INC. (US) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | NFKB1, NFRKB, NFKBIA | METAP2 3681/4885NPC1 2238/4885HSD17B10 989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.