Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | TK2 | O00142 | 1/20 | 0.31 |
| ▸ | TK1 | P04183 | 1/20 | 0.31 |
| ▸ | CD74 | P04233 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12002968 | 0.82 | AGTR2 (0.41) | CYP2C9PTGDRPTGDR2 | |
| SCHEMBL3085148 | 0.81 | PTGDR2 (0.46) | DRD4SIGMAR1DRD2KCNH2CYP2C9 | |
| SCHEMBL12002810 | 0.79 | DRD4 (0.41) | DRD4SIGMAR1DRD2KCNH2PTGDR | |
| SCHEMBL2188346 | 0.77 | CYP2C9 (0.36) | DRD4DRD2CYP2C9PTGDRPTGDR2 | |
| SCHEMBL2187160 | 0.77 | CYP2C9 (0.37) | CYP2C9PTGDRPTGDR2 | |
| SCHEMBL2189400 | 0.75 | RB1 (0.36) | DRD4DRD2CYP2C9PTGDRPTGDR2 | |
| SCHEMBL2188133 | 0.71 | KCNA3 (0.41) | DRD2CYP2C9PTGDRPTGDR2 | |
| SCHEMBL2188978 | 0.70 | PSIP1 (0.33) | — | |
| SCHEMBL2190625 | 0.70 | PTGDR2 (0.41) | CYP2C9PTGDRPTGDR2 | |
| SCHEMBL3096538 | 0.68 | PTGDR2 (0.46) | CYP2C9PTGDRPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2492267-B1 | Indole derivatives as CRTH2 receptor antagonists in combination with a second active ingredient | MERCK SHARP & DOHME (US) | 2014-11-26 | — | — | EP | disclosed |
| EP-2401269-B1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-01-29 | — | — | EP | disclosed |
| EP-2492267-A1 | Indole derivatives as CRTH2 receptor antagonists in combination with a second active ingredient | Merck Sharp & Dohme Corp. (US) | 2012-08-29 | — | — | EP | disclosed |