Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | PSIP1 | O75475 | 3/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188346 | 0.86 | CYP2C9 (0.36) | CYP2C9PTGDRPTGDR2CYP3A4KCNQ2 | |
| SCHEMBL2189400 | 0.85 | RB1 (0.36) | CYP2C9PTGDRPTGDR2CYP3A4KCNQ2 | |
| SCHEMBL2188133 | 0.80 | KCNA3 (0.41) | CYP2C9PTGDRPTGDR2KMT2A | |
| SCHEMBL2188978 | 0.80 | PSIP1 (0.33) | PSIP1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2190625 | 0.80 | PTGDR2 (0.41) | CYP2C9PTGDRPTGDR2CYP3A4 | |
| SCHEMBL12002811 | 0.77 | DRD4 (0.39) | CYP2C9PTGDRPTGDR2 | |
| SCHEMBL12002968 | 0.77 | AGTR2 (0.41) | CYP2C9PTGDRPTGDR2 | |
| SCHEMBL15428825 | 0.74 | PTGDR2 (0.56) | CYP2C9PTGDRPTGDR2CYP3A4KDM4E | |
| SCHEMBL2187156 | 0.73 | PTGDR2 (0.39) | PTGDRPTGDR2PSIP1 | |
| SCHEMBL13279600 | 0.71 | CYP2C9 (0.46) | CYP2C9PTGDRPTGDR2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172263-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA LTD (CA) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172263-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | PTGER2, PTGDR2, PTGDR | CYP2C9 1320/4885PTGDR 3/4885PTGDR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.