Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 7/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12003341 | 1.00 | ALDH1A1 (0.48) | ALDH1A1GRM5IRAK4MAPTNPC1 | |
| SCHEMBL12003336 | 0.96 | ALDH1A1 (0.50) | ALDH1A1GRM5IRAK4MAPTNPC1 | |
| SCHEMBL12003457 | 0.91 | ALDH1A1 (0.53) | ALDH1A1GRM5MAPTNPC1LMNA | |
| SCHEMBL12018161 | 0.91 | ALDH1A1 (0.55) | ALDH1A1GRM5MAPTNPC1LMNA | |
| SCHEMBL12003471 | 0.91 | GRM5 (0.42) | ALDH1A1GRM5IRAK4MAPTNOX4 | |
| Hydrochloric Acid SCHEMBL15609960 | 0.90 | ALDH1A1 (0.54) | ALDH1A1GRM5MAPTNPC1LMNA | |
| SCHEMBL12003602 | 0.89 | GRM5 (0.43) | ALDH1A1GRM5IRAK4LMNAFFAR4 | |
| SCHEMBL12003350 | 0.86 | FFAR1 (0.45) | ALDH1A1GRM5MAPTNPC1LMNA | |
| SCHEMBL12003474 | 0.86 | GRM5 (0.44) | ALDH1A1GRM5MAPTLMNAKMO | |
| SCHEMBL16864370 | 0.86 | ALDH1A1 (0.49) | ALDH1A1GRM5MAPTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000176-B2 | Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same | EWHA University—Industry Collaboration Foundation (KR) | 2015-04-07 | — | — | US | claimed |
| US-20140088152-A1 | COMPOSITION FOR PREVENTING AND TREATING CARDIOVASCULAR DISEASES, CONTAINING PYRAZOLE DERIVATIVE | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-03-27 | — | — | US | claimed |
| US-20140066404-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-03-06 | — | — | US | claimed |
| US-20120220550-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY- INDUSTRY COLLABORATION FOUNDATION (KR) | 2012-08-30 | — | — | US | claimed |
| US-9000176-B2 | Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same | EWHA University—Industry Collaboration Foundation (KR) | 2015-04-07 | — | — | US | disclosed |
| US-20140088152-A1 | COMPOSITION FOR PREVENTING AND TREATING CARDIOVASCULAR DISEASES, CONTAINING PYRAZOLE DERIVATIVE | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-03-27 | — | — | US | disclosed |
| US-20140066404-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-03-06 | — | — | US | disclosed |
| US-8604210-B2 | Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2013-12-10 | — | — | US | disclosed |
| US-20120220550-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY- INDUSTRY COLLABORATION FOUNDATION (KR) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220550-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | PTH1R, VDR, SOST | ALDH1A1 2869/4885GRM5 1884/4885IRAK4 1098/4885 |
| US-20140066404-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | PTH1R, VDR, SOST | ALDH1A1 2869/4885GRM5 1884/4885IRAK4 1098/4885 |
| US-20140088152-A1 | COMPOSITION FOR PREVENTING AND TREATING CARDIOVASCULAR DISEASES, CONTAINING PYRAZOLE DERIVATIVE | FABP3, PPARD, SIRT3 | ALDH1A1 2049/4885GRM5 2786/4885IRAK4 1506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.