Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16281294 | 0.89 | GPR119 (0.42) | GPR119SMN1; SMN2P2RX4BCHETSHR | |
| SCHEMBL12988801 | 0.76 | CHRM2 (0.42) | GPR119 | |
| SCHEMBL11993154 | 0.75 | TSHR (0.31) | GPR119TSHR | |
| SCHEMBL11993156 | 0.72 | GPR119 (0.32) | GPR119P2RX4 | |
| SCHEMBL12271427 | 0.69 | — | — | |
| SCHEMBL13243110 | 0.69 | — | — | |
| SCHEMBL12199133 | 0.69 | GPR119 (0.43) | GPR119 | |
| SCHEMBL12320731 | 0.68 | TSHR (0.41) | TSHR | |
| SCHEMBL4028667 | 0.68 | PIK3CD (0.32) | GPR119TSHR | |
| SCHEMBL16281285 | 0.68 | TSHR (0.31) | GPR119TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9301929-B2 | Substituted biaryl derivatives and methods of use thereof | MERCK SHARP & DOHME CORP. (US) | 2016-04-05 | — | — | US | disclosed |
| US-8907095-B2 | Bicyclic heterocycle derivatives and their use as modulators of the activity of GPR119 | MERCK SHARP & DOHME CORP. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20120220614-A1 | SUBSTITUTED BIARYL DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC | 2012-08-30 | — | — | US | disclosed |
| US-20110212938-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS MODULATORS OF THE ACTIVITY OF GPR119 | SCHERING CORPORATION | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220614-A1 | SUBSTITUTED BIARYL DERIVATIVES AND METHODS OF USE THEREOF | GPR119, GPR88, GCGR | GPR119 1/4885SMN1; SMN2 3607/4885P2RX4 983/4885 |
| US-20110212938-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS MODULATORS OF THE ACTIVITY OF GPR119 | GPR119, GPR88, GPR180 | GPR119 1/4885SMN1; SMN2 4300/4885P2RX4 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.