Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.60 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.60 |
| ▸ | THPO | P40225 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345357 | 1.00 | PTGS2 (0.60) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL21556465 | 0.82 | MAPT (0.44) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| Ketoprofen SCHEMBL8371567 | 0.79 | PTGS1 (0.85) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL1344993 | 0.77 | PTGS1 (0.72) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL6717009 | 0.77 | PTGS1 (0.72) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL1344992 | 0.77 | PTGS1 (0.72) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| Ketoprofen SCHEMBL27834432 | 0.77 | PTGS1 (0.88) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL602096 | 0.76 | PTGS2 (0.69) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| R-Ketoprofen SCHEMBL195303 | 0.76 | PTGS1 (1.00) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| Ketoprofen SCHEMBL679920 | 0.76 | PTGS1 (1.00) | PTGS2PTGS1MAPTCXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229942-B1 | 2-Aryl-propionic acids and pharmaceutical compositions containing them | DOMPE SPA (IT) | 2012-08-29 | — | — | EP | disclosed |
| US-8063242-B2 | for treatment of neutrofil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bollous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis; prevention and treatment of damages caused by ischemia and reperfusion | DOMPE PHA.R.MA S.P.A. (IT) | 2011-11-22 | — | — | US | disclosed |
| US-8063242-B2 | for treatment of neutrofil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bollous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis; prevention and treatment of damages caused by ischemia and reperfusion | DOMPE PHA.R.MA S.P.A. (IT) | 2011-11-22 | — | — | US | disclosed |
| EP-2229942-A1 | 2-Aryl-propionic acids and pharmaceutical compositions containing them | Dompe S.p.A. (IT) | 2010-09-22 | — | — | EP | disclosed |