Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | IL2 | P60568 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.35 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28807231 | 0.81 | LTA4H (0.44) | LTA4HHPGDSIL2BRD4CHRNA7 | |
| SCHEMBL8229045 | 0.79 | LTA4H (0.42) | LTA4HHPGDSIL2BRD4BACE1 | |
| SCHEMBL12021842 | 0.79 | MAP4K4 (0.43) | LTA4HHPGDSIL2BRD4BACE1 | |
| SCHEMBL8281253 | 0.79 | GRIN2B (0.46) | LTA4HHPGDSIL2BRD4BACE1 | |
| SCHEMBL12021800 | 0.79 | LTA4H (0.46) | LTA4HHPGDSIL2BRD4BACE1 | |
| SCHEMBL24746118 | 0.76 | LTA4H (0.42) | LTA4HHPGDSIL2BRD4P2RX7 | |
| SCHEMBL377220 | 0.76 | IL2 (0.46) | LTA4HHPGDSIL2BRD4BACE1 | |
| SCHEMBL1127714 | 0.76 | LTA4H (0.42) | LTA4HHPGDSIL2BRD4BACE1 | |
| SCHEMBL8226440 | 0.76 | HPGDS (0.41) | LTA4HHPGDSIL2BRD4BACE1 | |
| SCHEMBL722557 | 0.74 | LTA4H (0.64) | LTA4HHPGDSBRD4CHRNA7CHRNA10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934227-B1 | 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2011-12-21 | — | — | EP | disclosed |
| WO-2007035542-A1 | 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2007-03-29 | — | — | WO | disclosed |