Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3619490 | 0.92 | RORC (0.42) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL12023787 | 0.84 | MITF (0.41) | ALDH1A1CASP7RORCLMNAMITF | |
| SCHEMBL3626980 | 0.78 | RORC (0.39) | ALDH1A1GAARORC | |
| SCHEMBL4639304 | 0.73 | RORC (0.42) | RORCMLYCDCETP | |
| SCHEMBL12023921 | 0.73 | MITF (0.49) | RORCHSD11B1MITFKMT2ATDP1 | |
| SCHEMBL3625569 | 0.67 | RORC (0.45) | KDM4EALDH1A1HPGDRORCLMNA | |
| SCHEMBL23838094 | 0.66 | HSD11B1 (0.50) | ALDH1A1TSHRMAPK1RORCPDK1 | |
| SCHEMBL21087697 | 0.66 | HSD11B1 (0.50) | ALDH1A1TSHRMAPK1RORCPDK1 | |
| SCHEMBL12024511 | 0.64 | KMT2A (0.52) | ALDH1A1GLAHPGDRORCSMN1; SMN2 | |
| SCHEMBL3624250 | 0.63 | RORC (0.40) | KDM4EALDH1A1GLAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392567-A1 | BENZOTHIAZINE DERIVATIVES AND THEIR USE AS LXR MODULATORS | Bristol-Myers Squibb Company (US) | 2011-12-07 | — | — | EP | disclosed |