Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 7/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3620207 | 0.89 | RORC (0.51) | RORCNR1I2NR1H2NR1H3SMN1; SMN2 | |
| SCHEMBL12023875 | 0.77 | LMNA (0.41) | RORCNR1I2NR1H2NR1H3HSD11B1 | |
| SCHEMBL12023897 | 0.74 | POLB (0.50) | RORCNOTUMPOLBCYP1A2CYP2C9 | |
| SCHEMBL3626261 | 0.70 | RORC (0.53) | RORCNR1I2NR1H2NR1H3NOTUM | |
| SCHEMBL3621138 | 0.67 | RORC (0.45) | RORCNR1I2NR1H2NR1H3 | |
| SCHEMBL3621143 | 0.67 | RORC (0.45) | RORCNR1I2NR1H2NR1H3 | |
| SCHEMBL7382580 | 0.65 | NOTUM (0.44) | RORCNR1I2NR1H2NR1H3NOTUM | |
| SCHEMBL3619476 | 0.64 | RORC (0.57) | RORCNR1I2NR1H2NR1H3NOTUM | |
| SCHEMBL11603760 | 0.64 | NR1H3 (0.54) | RORCNR1I2NR1H2NR1H3NOTUM | |
| SCHEMBL7669092 | 0.64 | MAPT (0.43) | RORCNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392567-A1 | BENZOTHIAZINE DERIVATIVES AND THEIR USE AS LXR MODULATORS | Bristol-Myers Squibb Company (US) | 2011-12-07 | — | — | EP | disclosed |