SCHEMBL120253

SCHEMBL120253

Cc1ccc(-c2nnc(-c3ccc(C)cc3)o2)cc1

nearest known ligand 0.83

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 15/20 0.83
RAB9A P51151 15/20 0.83
SMN1; SMN2 Q16637 10/20 0.83
HPGD P15428 5/20 0.83
NFKB1 P19838 2/20 0.83
NFKB2 Q00653 2/20 0.83
RELA Q04206 2/20 0.83
POLB P06746 1/20 0.83
KMT2A Q03164 3/20 0.73
KDM4E B2RXH2 8/20 0.72
ALDH1A1 P00352 5/20 0.66
CYP1A2 P05177 2/20 0.66
CYP3A4 P08684 2/20 0.66
CYP2C9 P11712 2/20 0.66
HSD17B10 Q99714 2/20 0.66
TSHR P16473 2/20 0.66
MAPT P10636 4/20 0.63
NPSR1 Q6W5P4 2/20 0.63
MEN1 O00255 2/20 0.63
GAA P10253 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6015198 1.00 NPC1 (0.83) NPC1RAB9ASMN1; SMN2HPGDNFKB1
SCHEMBL13231671 0.97 NPC1 (0.79) NPC1RAB9ASMN1; SMN2HPGDNFKB1
SCHEMBL12918681 0.93 NPC1 (0.73) NPC1RAB9ASMN1; SMN2HPGDNFKB1
SCHEMBL10330356 0.91 NPC1 (0.70) NPC1RAB9ASMN1; SMN2HPGDNFKB1
SCHEMBL762284 0.91 NPC1 (1.00) NPC1RAB9ASMN1; SMN2HPGDNFKB1
SCHEMBL14818889 0.91 NPC1 (1.00) NPC1RAB9ASMN1; SMN2HPGDNFKB1
SCHEMBL12354772 0.91 NPC1 (0.70) NPC1RAB9ASMN1; SMN2HPGDNFKB1
SCHEMBL13231654 0.89 NPC1 (0.68) NPC1RAB9ASMN1; SMN2HPGDNFKB1
SCHEMBL21673239 0.89 NPC1 (0.96) NPC1RAB9ASMN1; SMN2HPGDNFKB1
SCHEMBL19010395 0.89 NPC1 (0.79) NPC1RAB9ASMN1; SMN2HPGDNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 357 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060255322-A1 Methods and compositions for improved electrophoretic display performance WU ZARNG-ARH G 2006-11-16 US claimed
EP-1529242-A2 PROTECTING LAYER WITH ADDITIVES FOR ELECTROPHORETIC DISPLAY, METHOD OF PROVIDING SUCH LAYER, AND ELECTROPHORETIC DISPLAY WITH SUCH A LAYER Sipix Imaging, Inc. (US) 2005-05-11 EP claimed
US-20040085619-A1 Novel Methods and compositions for improved electrophoretic display performance SIPIX IMAGING, INC. 2004-05-06 US claimed
WO-2004010206-A2 PROTECTING LAYER WITH ADDITIVES FOR ELECTROPHORETIC DISPLAY, METHOD OF PROVIDING SUCH LAYER, AND ELECTROPHORETIC DISPLAY WITH SUCH A LAYER SIPIX IMAGING, INC. (US) 2004-01-29 WO claimed
US-20220216422-A1 Electroluminescent Device UDC IRELAND LTD (IE) 2022-07-07 US disclosed
US-11217752-B2 Diketopyrrolopyrrole polymers as organic semiconductors BASF SE (DE) 2022-01-04 US disclosed
WO-2021017214-A1 ELECTROLUMINESCENT POLYMER, PREPARATION METHOD AND APPLICATION THEREOF 华南理工大学 2021-02-04 WO disclosed
WO-2020158795-A1 LIQUID CRYSTAL ALIGNING AGENT, LIQUID CRYSTAL ALIGNMENT FILM USING SAME, AND LIQUID CRYSTAL DISPLAY ELEMENT 日産化学株式会社 2020-08-06 WO disclosed
US-10431745-B2 Diketopyrrolopyrrole polymers for use in organic field effect transistors BASF SE (DE) 2019-10-01 US disclosed
US-10424737-B2 Diketopyrrolopyrrole polymers as organic semiconductors BASF SE (DE) 2019-09-24 US disclosed
EP-2518111-B1 COMPOSITION AND LUMINESCENT ELEMENT OBTAINED USING SAME SUMITOMO CHEMICAL CO (JP) 2019-03-13 EP disclosed
US-10224484-B2 Diketopyrrolopyrrole polymers for use in organic field effect transistors BASF SE (DE) 2019-03-05 US disclosed
US-20060036097-A1 Oxadiazole metallic complexes and their electronic and opto-electronic applications MERCK PATENT GMBH (DE) 2006-02-16 US disclosed
EP-1529242-A2 PROTECTING LAYER WITH ADDITIVES FOR ELECTROPHORETIC DISPLAY, METHOD OF PROVIDING SUCH LAYER, AND ELECTROPHORETIC DISPLAY WITH SUCH A LAYER Sipix Imaging, Inc. (US) 2005-05-11 EP disclosed
US-20050007648-A1 Methods and compositions for improved electrophoretic display performance E INK CORPORATION 2005-01-13 US disclosed
US-20040085619-A1 Novel Methods and compositions for improved electrophoretic display performance SIPIX IMAGING, INC. 2004-05-06 US disclosed
WO-2004010206-A2 PROTECTING LAYER WITH ADDITIVES FOR ELECTROPHORETIC DISPLAY, METHOD OF PROVIDING SUCH LAYER, AND ELECTROPHORETIC DISPLAY WITH SUCH A LAYER SIPIX IMAGING, INC. (US) 2004-01-29 WO disclosed
EP-1075497-A1 POLYMERS CONTAINING OPTICAL BRIGHTENER COMPOUNDS COPOLYMERIZED THEREIN AND METHODS OF MAKING AND USING THEREFOR EASTMAN CHEMICAL COMPANY (US) 2001-02-14 EP disclosed
US-6150494-A POLYESTERS WITH AMIDES OR SULFONATES FOR OPTICAL BRIGHTENERS EASTMAN CHEMICAL COMPANY (US) 2000-11-21 US disclosed
WO-1999055761-A1 POLYMERS CONTAINING OPTICAL BRIGHTENER COMPOUNDS COPOLYMERIZED THEREIN AND METHODS OF MAKING AND USING THEREFOR EASTMAN CHEMICAL COMPANY (US) 1999-11-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060036097-A1 Oxadiazole metallic complexes and their electronic and opto-electronic applications OXA1L, PPOX, MT-CO3 NPC1 3772/4885RAB9A 4032/4885SMN1; SMN2 3817/4885
US-20220216422-A1 Electroluminescent Device PNPO, ODC1, AXL NPC1 4737/4885RAB9A 2872/4885SMN1; SMN2 2385/4885
US-10424737-B2 Diketopyrrolopyrrole polymers as organic semiconductors PIN1, PPOX, DDT NPC1 4043/4885RAB9A 1829/4885SMN1; SMN2 3951/4885
US-11217752-B2 Diketopyrrolopyrrole polymers as organic semiconductors ARPC4, DRD1, DRD4 NPC1 4672/4885RAB9A 3955/4885SMN1; SMN2 2988/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.