Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23918549 | 0.85 | TYR (0.64) | TYRKDM4EMAPK1PTGS1PTGS2 | |
| SCHEMBL30075786 | 0.85 | TYR (0.64) | TYRKDM4EMAPK1PTGS1PTGS2 | |
| SCHEMBL1137519 | 0.78 | TYR (0.56) | TYRKDM4EMAPK1PTGS1PTGS2 | |
| SCHEMBL11554074 | 0.78 | TYR (0.56) | TYRKDM4EMAPK1PTGS1PTGS2 | |
| SCHEMBL9405638 | 0.78 | TYR (0.56) | TYRKDM4EMAPK1PTGS1PTGS2 | |
| SCHEMBL2086915 | 0.76 | TYR (0.54) | TYRKDM4EMAPK1PTGS1PTGS2 | |
| SCHEMBL6546345 | 0.76 | KDM4E (0.59) | TYRKDM4EMAPK1PTGS1PTGS2 | |
| SCHEMBL23623944 | 0.76 | TYR (0.54) | TYRKDM4EMAPK1PTGS1PTGS2 | |
| SCHEMBL16105804 | 0.76 | KDM4E (0.59) | TYRKDM4EMAPK1PTGS1PTGS2 | |
| SCHEMBL24246237 | 0.76 | PTGS1 (0.60) | TYRKDM4EMAPK1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130287687-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | UNIV EMORY (US) | 2013-10-31 | — | — | US | disclosed |
| US-8551996-B2 | Compounds, compositions, methods of synthesis, and methods of treatment | EMORY UNIVERSITY (US) | 2013-10-08 | — | — | US | disclosed |
| US-20110305636-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | EMORY UNIVERSITY (US) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110305636-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | CRH, CRHR1, CRHR2 | TYR 652/4885KDM4E 3113/4885MAPK1 538/4885 |
| US-20130287687-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | CRH, CRHR1, CRHR2 | TYR 525/4885KDM4E 4628/4885MAPK1 1417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.