Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 5/20 | 0.39 |
| ▸ | FYN | P06241 | 4/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202379 | 0.86 | NTRK1 (0.47) | NTRK1NTRK3NTRK2KDM4ELMNA | |
| SCHEMBL19613847 | 0.84 | NTRK1 (0.39) | NTRK1NTRK3NTRK2KDM4ELMNA | |
| SCHEMBL1203816 | 0.82 | CXCR1 (0.52) | NTRK1NTRK3NTRK2MAPTCXCR1 | |
| SCHEMBL1202454 | 0.82 | CXCR1 (0.52) | NTRK1NTRK3NTRK2MAPTCXCR1 | |
| SCHEMBL1202165 | 0.82 | CXCR1 (0.52) | NTRK1NTRK3NTRK2LMNAMAPT | |
| SCHEMBL2902263 | 0.81 | PPARA (0.39) | KDM4EMAPTCXCR1CXCR2TGFBR1 | |
| SCHEMBL1202088 | 0.74 | FYN (0.63) | NTRK1NTRK3NTRK2KDM4EFYN | |
| SCHEMBL16935984 | 0.72 | TGFBR1 (0.40) | NTRK1NTRK3NTRK2KDM4ELMNA | |
| SCHEMBL1203558 | 0.71 | KDM4E (0.47) | NTRK1NTRK3NTRK2KDM4EMAPT | |
| SCHEMBL1203079 | 0.71 | KCNH2 (0.44) | NTRK1NTRK3NTRK2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2011-02-24 | — | — | US | disclosed |
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | PIM1, PIM3, PIM2 | NTRK1 755/4885NTRK3 756/4885NTRK2 2000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.