Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 5/20 | 0.52 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202454 | 0.92 | CXCR1 (0.52) | CXCR1CXCR2KCNH2MAPTMAPK1 | |
| SCHEMBL1203816 | 0.92 | CXCR1 (0.52) | CXCR1CXCR2KCNH2FYNMAPT | |
| SCHEMBL1203027 | 0.82 | NTRK1 (0.48) | CXCR1CXCR2KCNH2FYNMAPT | |
| SCHEMBL1203131 | 0.80 | FYN (0.53) | CXCR1CXCR2FYNMAPTTP53 | |
| SCHEMBL1203558 | 0.80 | KDM4E (0.47) | CXCR1CXCR2KCNH2MAPTNTRK1 | |
| SCHEMBL1202971 | 0.79 | CCNA2 (0.51) | KCNH2FYNMAPTTP53CCNA2 | |
| SCHEMBL1203079 | 0.77 | KCNH2 (0.44) | CXCR1CXCR2KCNH2FYNMAPT | |
| SCHEMBL1203766 | 0.77 | CXCR1 (0.44) | CXCR1CXCR2KCNH2MAPTMAPK1 | |
| SCHEMBL1203391 | 0.74 | ALDH1A1 (0.46) | CXCR1CXCR2MAPTTP53MAPK1 | |
| SCHEMBL1202162 | 0.74 | FYN (0.51) | CXCR1CXCR2FYNNTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | PIM1, PIM3, PIM2 | CXCR1 2620/4885CXCR2 3383/4885KCNH2 944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.